Fill out the form to download the PDF file. This application highlight details how the Inscopix nVoke and nVision system were used in freely moving animals to condition real-time place preference using zone occupancy-based cues to inform optogenetic stimulation of a known reward circuit while simultaneously imaging GCaMP activity in the nucleus accumbens. This application describes in detail how it works with data examples analyzed in IDEAS, resulting from the use of nVoke and nVision.