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Develop with the Inscopix Discovery Lab

Transforming preclinical drug development with in vivo brain imaging and behavior is our mission. We partner with pharma companies to provide critical insights into target engagement, dose-finding, pharmacodynamics, efficacy, lead candidate selection, and more.

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Our Services

The Inscopix Discovery Lab is a state-of-the-art in vivo rodent R&D facility staffed by neuroscientists expert in brain imaging and behavior. We conduct fee-for-service contract research studies in support of preclinical programs, offering several standardized assays as well as custom neurobehaviorial studies.

Disease Phenotyping and Efficacy

Inform target engagement studies and efficacy assessments

Test the ability of compounds to restore normal function in disease-relevant circuits (Parkinson’s, Alzheimer’s, Schizophrenia)

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Comparative Drug Profiling

Guide dose-finding studies and lead candidate selection

Compare the neurobehavioral profile of compounds to a library of approved and failed psychiatric drugs

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Vascular Imaging
Assay

Support target validation studies and screening of novel migraine therapies

Conduct real-time measurements of red blood cell velocity and vessel diameter in response to vasoactive substances

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Access our Neuroscience 2024 Presentations

The Inscopix Discovery Lab recently presented their latest innovative preclinical research at Neuroscience 2024 in Chicago, highlighting unique findings and product developments that offer hope for future neurotherapeutic insights into brain function and disease.​

Download PDFs from our poster sessions at Neuroscience 2024.​

Click the button and fill out the form to download the files.​

  • Poster #1: Miniscope-based in vivo blood vessel imaging enables a novel assay for testing migraine therapeutic candidates​
  • Poster #2: A circuit-based, neurobehavioral assay for preclinical antidepressant profiling​
  • Poster #3: Preclinical neurobehavioral profiling of antipsychotics through miniscope calcium imaging​
  • Poster #4: Miniscope-based neural circuit profiling in freely behaving animals for preclinical therapeutic assessment​
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Why Inscopix?

The preclinical phase of neurotherapeutic drug development is not predictive of clinical performance, leading to too many late-stage failures, which is costly and a waste of time. It is critical to understand how candidate therapies engage disease-relevant circuits in vivo in the intact brain during active behavior.

At the Inscopix Discovery Lab:
We provide deep preclinical insights using advanced imaging and behavioral tools, powered by state-of-the-art analytics to drive drug development.

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Custom Studies and Emerging Applications

We offer neurobehavioral studies based on emerging applications to meet our clients’ specific research needs. Our services include biomarker identification and phenotyping in your chosen disease model, acute drug response analysis, and comparative profiling for any brain region. Additionally, we gather adaptive response data to chronic pharmacological treatments, ranging from days to months.

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About Us

Our team handles every aspect of your study from beginning to end.

Facilities: 2,000 sq. ft. lab, rodent vivarium, state-of-the-art equipment
Team: Neuroscientists with experimental and computational expertise

Frequently Asked Questions

How customizable can I make my project?

We specialize in designing neurobehavioral studies for your specific needs, including:
1. Biomarker identification and phenotyping in the disease model of your choice
2. Acute drug response and comparative profiling in your preferred brain region
3. Adaptive response to chronic pharmacological treatment over days, weeks or months

What are the typical end results of a project?

The Inscopix Discovery Lab works with clients to define the final output desired, whether it be a fully written report, comprehensive graphed analyses, or access to raw data.

Can you perform preclinical studies with Schedule 1 drugs?

Yes. The Inscopix Discovery Lab is one of the only in vivo neuroscience labs in the US with a Schedule 1 license. Contact us to learn more.

Do you follow animal welfare guidelines?

Yes, we adhere to strict standards as defined by US government animal welfare regulations. Contact us with any specific questions you may have.

How do I get started?

Complete the form below and one of our team members will be in contact. We’ll start with a discovery call and map out a program for you from there.

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