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Active dentate granule cells encode experience to promote the addition of adult-born hippocampal neurons


Authors: Gregory W. Kirschen, Jia Shen, Mu Tian, Bryce Schroeder, Jia Wang, Guoming Man, Song Wu and Shaoyu Ge
Publication: The Journal of Neuroscience
Date: April 3, 2017
Link to article: https://media.inscopix.com/cs/c/?cta_guid=458e7214-b0ce-445d-864d-2e69663a5382&…


The continuous addition of new dentate granule cells, exquisitely regulated by brain activity, renders the hippocampus plastic. However, how neural circuits encode experiences to impact the addition of adult-born neurons remains unknown. Here, we used endoscopic Ca2+ imaging to track the real-time activity of individual dentate granule cells in freely-behaving mice.

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