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Concussion increases CA1 activity during prolonged inactivity in a familiar environment

Technological Innovation

Authors: Shanti R. Tummala, Matthew A. Hemphill, Andrea Nam, David F. Meaney
Publication: Experimental Neurology
Date: August 17, 2020
Link to article: https://www.sciencedirect.com/science/article/pii/S0014488620302661?__hsfp=8229…


Although hippocampal damage plays a key role in impairments after concussion, differences in hippocampal information processing during recovery are unknown. Micro-endoscopic calcium imaging was performed before and after primary blast injury in freely behaving mice in two environments: their familiar home cage and a novel open field. Results show that after concussion CA1 activity increased in the familiar environment in which animals were awake and mostly immobile but was unaltered in a novel environment which the animals actively and constantly explored. As awake immobility parallels cognitive rest, a common treatment for patients, the results imply that prolonged cognitive rest may unwittingly impede concussion recovery.

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