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Engrams and circuits crucial for systems consolidation of a memory


Authors: Takashi Kitamura, Sachie K. Ogawa, Dheeraj S. Roy, Teruhiro Okuyama, Mark D. Morrissey, Lillian M. Smith, Roger L. Redondo, Susumu Tonegawa
Publication: Science
Date: April 7, 2017
Link to article: https://media.inscopix.com/cs/c/?cta_guid=8dbf6d9a-dcbc-4c00-8cc8-a4c93f01f911&…


Episodic memories initially require rapid synaptic plasticity within the hippocampus for their formation and are gradually consolidated in neocortical networks for permanent storage. However, the engrams and circuits that support neocortical memory consolidation have thus far been unknown.We found that neocortical prefrontal memory engram cells, which are critical for remote contextual fear memory, were rapidly generated during initial learning through inputs from both the hippocampal–entorhinal cortex network and the basolateral amygdala.

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