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Hippocampal ensemble dynamics timestamp events in long-term memory


Authors: Alon Rubin, Nitzan Geva, Liron Sheintuch, Yaniv Ziv
Publication: eLife
Date: December 18, 2015
Link to article: https://media.inscopix.com/cs/c/?cta_guid=3b8052f7-67e1-4f57-a8f2-ef635783aa75&…


The capacity to remember temporal relationships between different events is essential to episodic memory, but little is currently known about its underlying mechanisms. We performed time-lapse imaging of thousands of neurons over weeks in the hippocampal CA1 of mice as they repeatedly visited two distinct environments. Longitudinal analysis exposed ongoing environment-independent evolution of episodic representations, despite stable place field locations and constant remapping between the two environments.

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