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Midbrain modulation of conditioned learning

Authors: Rizzi G et al.
Date: February 7, 2020
Link to article: https://www.biorxiv.org/content/10.1101/2020.02.07.936963v1


The firing activity of striatal cholinergic interneurons (CINs) is a neural correlate of conditioned learning. However, its circuitry is not entirely described. Here we report that midbrain GABA and Glutamate neurons discriminate auditory cues and encode the association of a predictive stimulus with a footshock. Through their mono- and di-synaptic inputs via the thalamic-parafasicular sub-nucleus onto CINs, they contribute to processing fear learning.

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