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Simultaneous recording of breathing and neural activity in awake behaving mice

Authors: Shijia Liu, Sung Han
Publication: STAR Protocols
Date: June 17, 2022
Link to article: https://doi.org/10.1016/j.xpro.2022.101412


This protocol provides a pipeline for simultaneous recording of breathing and neural activities in awake, behaving mice. Breathing is recorded with thermistor probes implanted in the nasal cavity, which can be easily integrated with neural activity monitoring approaches such as fiber photometry. Here, we detail the procedures of the thermistor probe assembly, surgery, recording system setup, and data analysis. This protocol can be applied to investigate respiratory physiology and breathing changes during natural behaviors.

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