December 2015

Drug discovery for CNS disorders has suffered a major setback for the past several years compared to drugs for non-CNS disorders. The success rate for CNS drug discovery requires understanding of the target physiology and its interaction with the target site. Another critical feature is predictive validity which can predict the efficacy of test compounds

Adult neurogenesis is a dynamic process and provides this region of the brain with exceptional structural plasticity. The dentate granule cell layer of the hippocampus is a primary neurogenic region in the adult brain where newborn neurons are locally generated within the subgranular zone and eventually integrated into existing circuits. These newborn neurons in the

Our picks from the best in neuroscience research from November.