Rat Archives - Inscopix

Neuronal Ensembles in the Infralimbic Cortex Dynamically Process Distinct Aspects of Hedonic Value

Seth W. Hurley et al.
Journal of Neuroscience | October 10, 2023
Hedonic processing is critical for guiding appropriate behavior, and the infralimbic cortex (IL) is a key neural substrate associated with this function in rodents and humans. We used deep brain, in vivo calcium imaging...

Dopamine error signal to actively cope with lack of expected rewards

SEIYA ISHINO et al.
Science Advances | March 10, 2023
Rewards are often elusive and uncertain, requiring persistent effort to obtain. But how do we continue pursuing uncertain rewards, even when our expectations are not met? It is crucial to develop the ability to actively...

Ca2+ imaging of self and other in medial prefrontal cortex during social dominance interactions in a tube test

Nuria Garcia-Font et al.
PNAS | July 26, 2022
The study of social dominance interactions between animals offers a window onto the decision-making involved in establishing dominance hierarchies and an opportunity to examine changes in social behavior observed in...

Disrupted population coding in the prefrontal cortex underlies pain aversion

Anna Li et al.
Cell Reports | November 9, 2021
The prefrontal cortex (PFC) regulates a wide range of sensory experiences. Chronic pain is known to impair normal neural response, leading to enhanced aversion. However, it remains unknown how nociceptive responses in...

Dentate Granule Cells Encode Reinforcement Learning

Jia Shen et al.
Scientific Reports | July 13, 2021
DGCs’ activity predicts auditory decisions after task learning

Reduced activity of GAD67 expressing cells in the reticular thalamus enhance thalamic excitatory activity and varicella zoster virus associated pain

Rebecca Hornung et al.
Neuroscience Letters | August 4, 2020
Within the reticular thalamic nucleus neurons express gamma aminobutyric acid (GABA) and these cells project to the ventral posteromedial thalamic nucleus. When GABA activity decreases the activity of excitatory cells...

Ca2+ imaging of neurons in freely moving rats with automatic post hoc histological identification

Philip Anner et al.
Journal of Neuroscience Methods | May 11, 2020
Background: Cognitive neuroscientists aim to understand behavior often based on the underlying activity of individual neurons. Recently developed miniaturized epifluorescence microscopes allow recording of cellular...

Increased Cocaine Motivation Is Associated with Degraded Spatial and Temporal Representations in IL-NAc Neurons

Courtney M. Cameron et al.
Neuron | May 14, 2019
Craving for cocaine progressively increases in cocaine users during drug-free periods, contributing to relapse. The projection from the infralimbic cortex to the nucleus accumbens shell (IL-NAc) is thought to inhibit...

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