Research article Archives - Page 21 of 23

Distinct hippocampal pathways mediate dissociable roles of context in memory retrieval

Chun Xu et al.
Cell | October 20, 2016
Memories about sensory experiences are tightly linked to the context in which they were formed. Memory contextualization is fundamental for the selection of appropriate behavioral reactions needed for survival, yet the...

Circuit-based interrogation of sleep control

Franz Weber et al.
Nature | October 5, 2016
Sleep is a fundamental biological process observed widely in the animal kingdom, but the neural circuits generating sleep remain poorly understood. Understanding the brain mechanisms controlling sleep requires the...

Ventral CA1 neurons store social memory

Teruhiro Okuyama et al.
Science | September 30, 2016
The medial temporal lobe, including the hippocampus, has been implicated in social memory. However, it remains unknown which parts of these brain regions and their circuits hold social memory. Here, we show that ventral...

A new design for a green calcium indicator with a smaller size and a reduced number of calcium-binding sites

Natalia V. Barykina et al.
Scientific Reports | September 28, 2016
Genetically encoded calcium indicators (GECIs) are mainly represented by two- or one-fluorophore-based sensors. One type of two-fluorophore-based sensor, carrying Opsanus troponin C (TnC) as the Ca2+-binding moiety, has...

Decreasing striatopallidal pathway function enhances motivation by energizing the initiation of goal-directed action

Fernanda Carvalho Poyraz et al.
The Journal of Neuroscience | June 1, 2016
Altered dopamine D2 receptor (D2R) binding in the striatum has been associated with abnormal motivation in neuropsychiatric disorders, including schizophrenia. Here, we tested whether motivational deficits observed in...

Calcium imaging of basal forebrain activity during innate and learned behavio

Thomas C. Harrison et al.
Frontiers in Neural Circuits | May 9, 2016
The basal forebrain (BF) plays crucial roles in arousal, attention, and memory, and its impairment is associated with a variety of cognitive deficits. The BF consists of cholinergic, GABAergic, and glutamatergic...

Neurons for hunger and thirst transmit a negative-valence teaching signal

J. Nicholas Betley et al.
Nature | April 27, 2016
Homeostasis is a biological principle for regulation of essential physiological parameters within a set range. Behavioural responses due to deviation from homeostasis are critical for survival, but motivational...

Large-scale fluorescence calcium-imaging methods for studies of long-term memory in behaving mammals

Pablo Jercog et al.
Cold Spring Harbor Perspectives In Biology | April 5, 2016
During long-term memory formation, cellular and molecular processes reshape how individual neurons respond to specific patterns of synaptic input. It remains poorly understood how such changes impact information...

Direct imaging of hippocampal epileptiform calcium motifs following kainic acid administration in freely behaving mice

Tamara K. Berdyyeva et al.
Frontiers in Neuroscience | February 29, 2016
Prolonged exposure to abnormally high calcium concentrations is thought to be a core mechanism underlying hippocampal damage in epileptic patients; however, no prior study has characterized calcium activity during...

Calcium imaging of sleep–wake related neuronal activity in the dorsal pons

Julia Cox et al.
Nature Communications | February 25, 2016
The dorsal pons has long been implicated in the generation of rapid eye movement (REM) sleep, but the underlying circuit mechanisms remain poorly understood. Using cell-type-specific microendoscopic Ca2+ imaging in and...

Visualization of cortical, subcortical and deep brain neural circuit dynamics during naturalistic mammalian behavior with head-mounted microscopes and chronically implanted lenses

Shanna L Resendez et al.
Nature Protocols | February 25, 2016
Genetically encoded calcium indicators for visualizing dynamic cellular activity have greatly expanded our understanding of the brain. However, owing to the light-scattering properties of the brain, as well as the size...

Hippocampal ensemble dynamics timestamp events in long-term memory

Alon Rubin et al.
eLife | December 18, 2015
The capacity to remember temporal relationships between different events is essential to episodic memory, but little is currently known about its underlying mechanisms. We performed time-lapse imaging of thousands of...

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