Research article Archives - Page 3 of 23

Two parabrachial Cck neurons involved in the feedback control of thirst or salt appetite

Takashi Matsuda et al.
Cell Reports | December 28, 2023
Thirst and salt appetite are temporarily suppressed after water and salt ingestion, respectively, before absorption; however, the underlying neural mechanisms remain unclear. The parabrachial nucleus (PBN) is the relay...

Neural correlate of reduced respiratory chemosensitivity during chronic epilepsy

Amol M. Bhandare et al.
Frontiers in Cellular Neuroscience | December 20, 2023
While central autonomic, cardiac, and/or respiratory dysfunction underlies sudden unexpected death in epilepsy (SUDEP), the specific neural mechanisms that lead to SUDEP remain to be determined. In this study, we took...

Functional imaging of nine distinct neuronal populations under a miniscope in freely behaving animals

Mary L. Phillips et al.
bioRxiv | December 14, 2023
Head-mounted miniscopes have allowed for functional fluorescence imaging in freely moving animals. However, current capabilities of state-of-the-art technology can record only up to two, spectrally distinct...

Prefrontal dynamics and encoding of flexible rule switching

Marco Nigro et al.
bioRiv | December 14, 2023
Behavioral flexibility, the ability to adjust behavioral strategies in response to changing environmental contingencies and internal demands, is fundamental to cognitive functions. Despite a large body of pharmacology...

Motor cortex somatostatin interneurons adaptively shape the structure of motor sequences

Jeong Oen Lee et al.
bioRxiv | November 29, 2023
The brain can flexibly reorganize motor sequence, or program, execution to efficiently reach positive outcomes. These behavioral adaptations are primarily driven by reinforcement learning, leading to structural and...

Emergence of task-related spatiotemporal population dynamics in transplanted neurons

Harman Ghuman et al.
Nature Communications | November 11, 2023
Loss of nervous system tissue after severe brain injury is a main determinant of poor functional recovery. Cell transplantation is a promising method to restore lost tissue and function, yet it remains unclear if...

Functional alterations of the prefrontal circuit underlying cognitive aging in mice

Huee Ru Chong et al.
Nature Communications | November 9, 2023
Executive function is susceptible to aging. How aging impacts the circuit-level computations underlying executive function remains unclear. Using calcium imaging and optogenetic manipulation during memory-guided...

Divergent Recruitment of Developmentally-Defined Neuronal Ensembles Supports Memory Dynamics

Vilde A. Kveim et al.
bioRxiv | November 6, 2023
Memories are dynamic constructs whose properties change with time and experience. The biological mechanisms underpinning these dynamics remain elusive, particularly concerning how shifts in the composition of...

Deep brain stimulation of thalamic nucleus reuniens promotes neuronal and cognitive resilience in an Alzheimer’s disease mouse model

Shiri Shoob et al.
Nature Communications | November 2, 2023
The mechanisms that confer cognitive resilience to Alzheimer’s Disease (AD) are not fully understood. Here, we describe a neural circuit mechanism underlying this resilience in a familial AD mouse model. In the...

Lateral hypothalamic proenkephalin neurons drive threat-induced overeating associated with a negative emotional state

In-Jee You et al.
Nature Communications | October 28, 2023
Psychological stressors, like the nearby presence of a predator, can be strong enough to induce physiological/hormonal alterations, leading to appetite changes. However, little is known about how threats can alter...

Dual color miniscope imaging of microvessels and neuronal activity in the hippocampus CA1 region of freely moving mice following alcohol administration

Kelsey North et al.
American Journal of Physiology | October 23, 2023
Moderate-to-heavy episodic (“binge”) drinking is the most common form of alcohol consumption in the United States. Alcohol at binge drinking concentrations reduces brain artery diameter in vivo and in vitro...

Context-invariant socioemotional encoding by prefrontal ensembles

Nicholas A. Frost et al.
bioRxiv | October 23, 2023
The prefrontal cortex plays a key role in social interactions, anxiety-related avoidance, and flexible context- dependent behaviors, raising the question: how do prefrontal neurons represent socioemotional information...

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