Basal forebrain Archives - Inscopix, Inc.

A neural circuit for male sexual behavior and reward

Daniel W. Bayless et al.
Cell | August 11, 2023
A study conducted by Bayless et al. explores the neural basis of innate male sexual behavior and its rewarding nature. Using nVista for calcium imaging and fiber photometry, the researchers identified a developmentally...

Neural dynamics underlying birdsong practice and performance

Jonnathan Singh Alvarado et al.
Nature | October 20, 2021
Musical and athletic skills are learned and maintained through intensive practice to enable precise and reliable performance for an audience. Consequently, understanding such complex behaviours requires insight into how...

An endogenous opioid circuit determines state-dependent reward consumption

Daniel C. Castro et al.
Nature | October 13, 2021
µ-Opioid peptide receptor (MOPR) stimulation alters respiration, analgesia and reward behaviour, and can induce substance abuse and overdose1,2,3. Despite its evident importance, the endogenous mechanisms for MOPR...

Dynamic dichotomy of accumbal population activity underlies cocaine sensitization

Ruud van Zessen et al.
eLife | October 5, 2021
Locomotor sensitization (LS) is an early behavioral adaptation to addictive drugs, driven by the increase of dopamine in the Nucleus Accumbens (NAc). However, the effect on accumbal population activity remains elusive....

Corticotropin-releasing factor neurons in the bed nucleus of the stria terminalis exhibit sex-specific pain encoding in mice

Waylin Yu et al.
Scientific Reports | June 14, 2021
The bed nucleus of the stria terminalis (BNST) plays an emerging role in pain regulation. Pharmacological studies have found that inhibiting corticotropin-releasing factor (CRF) signaling in the BNST can selectively...

A neuronal signature for monogamous reunion

Jennifer L. Scribner et al.
PNAS | May 7, 2020
Pair-bond formation depends vitally on neuromodulatory signaling within the nucleus accumbens, but the neuronal dynamics underlying this behavior remain unclear. Using 1-photon in vivo Ca2+ imaging in monogamous prairie...

Opposing Regulation of Cocaine Seeking by Glutamate and GABA Neurons in the Ventral Pallidum

Jasper A. Heinsbroek et al.
Cell Reports | February 11, 2020
Projections from the nucleus accumbens to the ventral pallidum (VP) regulate relapse in animal models of addiction. The VP contains GABAergic (VPGABA) and glutamatergic (VPGlu) neurons, and a subpopulation of GABAergic...

Calcium imaging of basal forebrain activity during innate and learned behavio

Thomas C. Harrison et al.
Frontiers in Neural Circuits | May 9, 2016
The basal forebrain (BF) plays crucial roles in arousal, attention, and memory, and its impairment is associated with a variety of cognitive deficits. The BF consists of cholinergic, GABAergic, and glutamatergic...

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Publication Category: Basal forebrain