Nucleus Accumbens Archives

Dynamic representation of appetitive and aversive stimuli in nucleus accumbens shell D1- and D2-medium spiny neurons

Ana Verónica Domingues et al.
bioRxiv | February 23, 2024
The nucleus accumbens (NAc) is a key brain region for motivated behaviors, yet how distinct neuronal populations encode appetitive or aversive stimuli remains undetermined. Using microendoscopic calcium imaging, we...

Error-related signaling in nucleus accumbens D2 receptor-expressing neurons guides inhibition-based choice behavior in mice

Tadaaki Nishioka et al.
Nature Communications | April 21, 2023
Learned associations between environmental cues and the outcomes they predict (cue-outcome associations) play a major role in behavioral control, guiding not only which responses we should perform, but also which we...

Dopamine error signal to actively cope with lack of expected rewards

SEIYA ISHINO et al.
Science Advances | March 10, 2023
Rewards are often elusive and uncertain, requiring persistent effort to obtain. But how do we continue pursuing uncertain rewards, even when our expectations are not met? It is crucial to develop the ability to actively...

Lateral NAc Shell D1 and D2 Neuronal Ensembles Concurrently Predict Licking Behavior and Categorize Sucrose Concentrations in a Context-dependent Manner

Alam Coss et al.
Neuroscience | June 15, 2022
The palatability and concentration of sweet foods promote hedonic feeding beyond homeostatic need. Understanding how neurons respond to sweet taste is thus of great importance. The dorsomedial nucleus accumbens shell...

Choice-selective sequences dominate in cortical relative to thalamic inputs to NAc to support reinforcement learning

Nathan F. Parker et al.
Cell Reports | May 17, 2022
How are actions linked with subsequent outcomes to guide choices? The nucleus accumbens, which is implicated in this process, receives glutamatergic inputs from the prelimbic cortex and midline regions of the thalamus....

Accumbens D2-MSN hyperactivity drives antipsychotic-induced behavioral supersensitivity

Anna Kruyer et al.
Molecular Psychiatry | August 4, 2021
Antipsychotic-induced dopamine supersensitivity, or behavioral supersensitivity, is a problematic consequence of long-term antipsychotic treatment characterized by the emergence of motor abnormalities, refractory...

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Publication Category: Nucleus Accumbens