Pons Archives - Inscopix, Inc.

Neural correlate of reduced respiratory chemosensitivity during chronic epilepsy

Amol M. Bhandare et al.
Frontiers in Cellular Neuroscience | December 20, 2023
While central autonomic, cardiac, and/or respiratory dysfunction underlies sudden unexpected death in epilepsy (SUDEP), the specific neural mechanisms that lead to SUDEP remain to be determined. In this study, we took...

Targeted activation of midbrain neurons restores locomotor function in mouse models of parkinsonism

Débora Masini et al.
Nature Communications | January 26, 2022
The pedunculopontine nucleus (PPN) is a locomotor command area containing glutamatergic neurons that control locomotor initiation and maintenance. These motor actions are deficient in Parkinson’s disease (PD), where...

Dichotomous dopaminergic and noradrenergic neural states mediate distinct aspects of exploitative behavioral states

Aaron C. Koralek et al.
Science Advances | July 23, 2021
The balance between exploiting known actions and exploring alternatives is critical for survival and hypothesized to rely on shifts in neuromodulation. We developed a behavioral paradigm to capture exploitative and...

Taste Responsiveness Embedded in PBN

Brooke C. Jarvie et al.
Nature Communications | January 11, 2021
Genetic identity of taste perceiving neurons

Hindbrain Double-Negative Feedback Mediates Palatability-Guided Food and Water Consumption

Rong Gong et al.
Cell | August 24, 2020
Hunger and thirst have distinct goals but control similar ingestive behaviors, and little is known about neural processes that are shared between these behavioral states. We identify glutamatergic neurons in the...

A Rare Mutation of β1-Adrenergic Receptor Affects Sleep/Wake Behaviors

Guangsen Shi et al.
Neuron | May 28, 2019
Sleep is crucial for our survival, and many diseases are linked to long-term poor sleep quality. Before we can use sleep to enhance our health and performance and alleviate diseases associated with poor sleep, a greater...

Intense threat switches dorsal raphe serotonin neurons to a paradoxical operational mode

Changwoo Seo et al.
Science | January 31, 2019
Survival depends on the selection of behaviors adaptive for the current environment. For example, a mouse should run from a rapidly looming hawk but should freeze if the hawk is coasting across the sky. Although...

Parabrachial CGRP Neurons Establish and Sustain Aversive Taste Memories

Jane Y. Chen et al.
Neuron | October 18, 2018
Animals have innate preferences for tastes accompanying calorically rich foods and aversions to tastes associated with potentially spoiled or toxic foods. In addition, they possess learning mechanisms to modify feeding...

Encoding of Danger by Parabrachial CGRP Neurons

Carlos A. Campos et al.
Nature | March 21, 2018
Animals must respond to various threats to survive. Neurons that express calcitonin gene-related peptide in the parabrachial nucleus (CGRPPBN neurons) relay sensory signals that contribute to satiation and pain-induced...

Oxytocin-receptor-expressing neurons in the parabrachial nucleus regulate fluid intake

Philip J. Ryan et al.
Nature Neuroscience | November 27, 2017
Brain regions that regulate fluid satiation are not well characterized, yet are essential for understanding fluid homeostasis. We found that oxytocin-receptor-expressing neurons in the parabrachial nucleus of mice...

Calcium imaging of sleep–wake related neuronal activity in the dorsal pons

Julia Cox et al.
Nature Communications | February 25, 2016
The dorsal pons has long been implicated in the generation of rapid eye movement (REM) sleep, but the underlying circuit mechanisms remain poorly understood. Using cell-type-specific microendoscopic Ca2+ imaging in and...

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