Thalamus Archives - Inscopix, Inc.

Unilateral Optogenetic Stimulation of Lhx6 Neurons in the Zona Incerta Increases REM sleep

Aurelio Vidal-Ortiz et al.
Sleep | August 21, 2023
To determine how a waking brain falls asleep researchers have monitored and manipulated activity of neurons and glia in various brain regions. While imaging GABA neurons in the zona incerta (ZI) we found a subgroup that...

A central alarm system that gates multi-sensory innate threat cues to the amygdala

Sukjae J. Kang et al.
Cell Reports | August 16, 2022
Perception of threats is essential for survival. Previous findings suggest that parallel pathways independently relay innate threat signals from different sensory modalities to multiple brain areas, such as the midbrain...

Sound induces analgesia through corticothalamic circuits

Wenjie Zhou et al.
Science | July 7, 2022
Sound—including music and noise—can relieve pain in humans, but the underlying neural mechanisms remain unknown. We discovered that analgesic effects of sound depended on a low (5-decibel) signal-to-noise ratio...

Choice-selective sequences dominate in cortical relative to thalamic inputs to NAc to support reinforcement learning

Nathan F. Parker et al.
Cell Reports | May 17, 2022
How are actions linked with subsequent outcomes to guide choices? The nucleus accumbens, which is implicated in this process, receives glutamatergic inputs from the prelimbic cortex and midline regions of the thalamus....

Single cell plasticity and population coding stability in auditory thalamus upon associative learning

James Alexander Taylor et al.
Nature Communications | April 26, 2021
Cortical and limbic brain areas are regarded as centres for learning. However, how thalamic sensory relays participate in plasticity upon associative learning, yet support stable long-term sensory coding remains...

Reduced activity of GAD67 expressing cells in the reticular thalamus enhance thalamic excitatory activity and varicella zoster virus associated pain

Rebecca Hornung et al.
Neuroscience Letters | August 4, 2020
Within the reticular thalamic nucleus neurons express gamma aminobutyric acid (GABA) and these cells project to the ventral posteromedial thalamic nucleus. When GABA activity decreases the activity of excitatory cells...

Stress peptides sensitize fear circuitry to promote passive coping

Pinelopi Pliota et al.
Molecular Psychiatry | June 18, 2018
Survival relies on optimizing behavioral responses through experience. Animals often react to acute stress by switching to passive behavioral responses when coping with environmental challenge. Despite recent advances...

Inscopix Publications

Publication Category: Thalamus