Motor Learning Archives - Inscopix, Inc.

Tripartite extended amygdala–basal ganglia CRH circuit drives locomotor activation and avoidance behavior

Simon Chang et al.
Science Advances | November 16, 2022
An adaptive stress response involves various mediators and circuits orchestrating a complex interplay of physiological, emotional, and behavioral adjustments. We identified a population of corticotropin-releasing...

Complete representation of action space and value in all dorsal striatal pathways

Moritz Weglage et al.
Cell Reports | July 27, 2021
The dorsal striatum plays a central role in the selection, execution, and evaluation of actions. An emerging model attributes action selection to the matrix and evaluation to the striosome compartment. Here, we use...

Head-mounted microendoscopic calcium imaging in dorsal premotor cortex of behaving rhesus macaque

Anil Bollimunta et al.
Cell Reports | June 15, 2021
Microendoscopic calcium imaging with one-photon miniature microscopes enables unprecedented readout of neural circuit dynamics during active behavior in rodents. In this study, we describe successful application of this...

In vivo Calcium Imaging in Mouse Inferior Olive

Da Guo et al.
JOVE | June 10, 2021
Inferior olive (IO), a nucleus in the ventral medulla, is the only source of climbing fibers that form one of the two input pathways entering the cerebellum. IO has long been proposed to be crucial for motor control and...

Transient dopamine neuron activity precedes and encodes the vigor of contralateral movements

Marcelo D Mendonça et al.
bioRxiv | April 20, 2021
Dopamine neurons (DANs) in the substantia nigra pars compacta (SNc) have been related to movement vigor, and loss of these neurons leads to bradykinesia in Parkinson’s disease. However, it remains unclear whether DANs...

The Striatum Organizes 3D Behavior via Moment-to-Moment Action Selection

Jeffrey E. Markowitz et al.
Cell | May 17, 2018
Many naturalistic behaviors are built from modular components that are expressed sequentially. Although striatal circuits have been implicated in action selection and implementation, the neural mechanisms that compose...

Deconstruction of Corticospinal Circuits for Goal-Directed Motor Skills

et al.
Cell | September 21, 2017
Corticospinal neurons (CSNs) represent the direct cortical outputs to the spinal cord and play important roles in motor control across different species. However, their organizational principle remains unclear. By using...

Mesoscopic patterns of neural activity support songbird cortical sequences

Jeffrey E. Markowitz et al.
PLOS Biology | June 3, 2015
Time-locked sequences of neural activity can be found throughout the vertebrate forebrain in various species and behavioral contexts. From “time cells” in the hippocampus of rodents to cortical activity controlling...

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Publication Category: Motor Learning