Social behaviors Archives - Inscopix, Inc.

A persistent prefrontal reference frame across time and task rules

Hannah Muysers et al.
Nature Communications | March 8, 2024
Behavior can be remarkably consistent, even over extended time periods, yet whether this is reflected in stable or ‘drifting’ neuronal responses to task features remains controversial. Here, we find a persistently...

Differential contribution of distinct neuronal populations to danger representations

Ana Paula Menegolla et al.
bioRxiv | January 24, 2024
The recognition of specific stimuli and contexts in dangerous situations determines the expression of behaviors needed to appropriately cope with each threatening encounter. Moreover, the detection of common features...

Prefrontal dynamics and encoding of flexible rule switching

Marco Nigro et al.
bioRiv | December 14, 2023
Behavioral flexibility, the ability to adjust behavioral strategies in response to changing environmental contingencies and internal demands, is fundamental to cognitive functions. Despite a large body of pharmacology...

Context-invariant socioemotional encoding by prefrontal ensembles

Nicholas A. Frost et al.
bioRxiv | October 23, 2023
The prefrontal cortex plays a key role in social interactions, anxiety-related avoidance, and flexible context- dependent behaviors, raising the question: how do prefrontal neurons represent socioemotional information...

Genetically- and spatially-defined basolateral amygdala neurons control food consumption and social interaction

Hansol Lim et al.
bioRxiv | October 17, 2023
The basolateral amygdala (BLA) contains discrete neuronal circuits that integrate positive or negative emotional information and drive the appropriate innate and learned behaviors. Whether these circuits consist of...

Hormone-mediated neural remodeling orchestrates parenting onset during pregnancy

RACHIDA AMMARI et al.
Science | October 5, 2023
During pregnancy, physiological adaptations prepare the female body for the challenges of motherhood. Becoming a parent also requires behavioral adaptations. Such adaptations can occur as early as during pregnancy, but...

Early life stress impairs VTA coordination of BLA network and behavioral states

Bradly T. Stone et al.
bioRxiv | September 17, 2023
Motivated behaviors, such as social interactions, are governed by the interplay between mesocorticolimbic structures, such as the ventral tegmental area (VTA), basolateral amygdala (BLA), and medial prefrontal cortex...

The respective activation and silencing of striatal direct and indirect pathway neurons support behavior encoding

Christophe Varin et al.
Nature Communications | August 17, 2023
The basal ganglia are known to control actions and modulate movements. Neuronal activity in the two efferent pathways of the dorsal striatum is critical for appropriate behavioral control. Previous evidence has led to...

A neural circuit for male sexual behavior and reward

Daniel W. Bayless et al.
Cell | August 11, 2023
A study conducted by Bayless et al. explores the neural basis of innate male sexual behavior and its rewarding nature. Using nVista for calcium imaging and fiber photometry, the researchers identified a developmentally...

A neural mechanism for discriminating social threat from social safety

Pegah Kassraian et al.
bioRxiv | July 27, 2023
The ability to distinguish a threatening from non-threatening conspecific based on past experience is critical for adaptive social behaviors. Although recent progress has been made in identifying the neural circuits...

Active experience, not time, determines within-day representational drift in dorsal CA1

Dorgham Khatib et al.
Neuron | June 13, 2023
Memories of past events can be recalled long after the event, indicating stability. But new experiences are also integrated into existing memories, indicating plasticity. In the hippocampus, spatial representations are...

Self-organization of songbird neural sequences during social isolation

Emily L Mackevicius et al.
eLife | May 30, 2023
Emily L. Mackevicius et al., using the Inscopix nVista tool, investigated whether the formation of sequences in the high vocal center (HVC) of songbirds depends on prior exposure to a tutor song. They found that even in...

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Publication Category: Social behaviors