Social behaviors Archives - Inscopix, Inc.

The hippocampal CA2 region discriminates social threat from social safety

Pegah Kassraian et al.
Nature Neuroscience | October 15, 2024
The dorsal cornu ammonis 2 (dCA2) region of the hippocampus enables the discrimination of novel from familiar conspecifics. However, the neural bases for more complex social–spatial episodic memories are unknown. Here...

A line attractor encoding a persistent internal state requires neuropeptide signaling

George Mountoufaris et al.
Cell | August 26, 2024
Internal states drive survival behaviors, but their neural implementation is poorly understood. Recently, we identified a line attractor in the ventromedial hypothalamus (VMH) that represents a state of aggressiveness....

Genetically- and spatially-defined basolateral amygdala neurons control food consumption and social interaction

Hansol Lim et al.
Nature Communications | August 11, 2024
The basolateral amygdala (BLA) contains discrete neuronal circuits that integrate positive or negative emotional information and drive the appropriate innate and learned behaviors. Whether these circuits consist of...

Gustatory Thalamic Neurons Mediate Aversive Behaviors

Feng Cao et al.
bioRxiv | July 30, 2024
The parvicellular part of the ventral posteromedial nucleus (VPMpc) of the thalamus, also known as the gustatory thalamus, receives input from the parabrachial nucleus and relays taste sensation to the gustatory (or...

Hyperactivity of indirect pathway-projecting spiny projection neurons promotes compulsive behavior

Sean C. Piantadosi et al.
Nature Communications | May 24, 2024
Compulsive behaviors are a hallmark symptom of obsessive compulsive disorder (OCD). Striatal hyperactivity has been linked to compulsive behavior generation in correlative studies in humans and causal studies in...

Cortico-cortical transfer of socially derived information gates emotion recognition

Daniel Dautan et al.
Nature Neuroscience | May 20, 2024
Emotion recognition and the resulting responses are important for survival and social functioning. However, how socially derived information is processed for reliable emotion recognition is incompletely understood....

Modulation of aggression by social novelty recognition memory in the hippocampal CA2 region

Andres Villegas et al.
bioRxiv | May 4, 2024
The dorsal CA2 subregion (dCA2) of the hippocampus exerts a critical role in social novelty recognition (SNR) memory and in the promotion of social aggression. Whether the social aggression and SNR memory functions of...

A persistent prefrontal reference frame across time and task rules

Hannah Muysers et al.
Nature Communications | March 8, 2024
Behavior can be remarkably consistent, even over extended time periods, yet whether this is reflected in stable or ‘drifting’ neuronal responses to task features remains controversial. Here, we find a persistently...

Differential contribution of distinct neuronal populations to danger representations

Ana Paula Menegolla et al.
bioRxiv | January 24, 2024
The recognition of specific stimuli and contexts in dangerous situations determines the expression of behaviors needed to appropriately cope with each threatening encounter. Moreover, the detection of common features...

Prefrontal dynamics and encoding of flexible rule switching

Marco Nigro et al.
bioRiv | December 14, 2023
Behavioral flexibility, the ability to adjust behavioral strategies in response to changing environmental contingencies and internal demands, is fundamental to cognitive functions. Despite a large body of pharmacology...

Context-invariant socioemotional encoding by prefrontal ensembles

Nicholas A. Frost et al.
bioRxiv | October 23, 2023
The prefrontal cortex plays a key role in social interactions, anxiety-related avoidance, and flexible context- dependent behaviors, raising the question: how do prefrontal neurons represent socioemotional information...

Hormone-mediated neural remodeling orchestrates parenting onset during pregnancy

RACHIDA AMMARI et al.
Science | October 5, 2023
During pregnancy, physiological adaptations prepare the female body for the challenges of motherhood. Becoming a parent also requires behavioral adaptations. Such adaptations can occur as early as during pregnancy, but...

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Publication Category: Social behaviors