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Distinct hippocampal pathways mediate dissociable roles of context in memory retrieval


Authors: Chun Xu, Sabine Krabbe, Jan Gründemann, Paolo Botta, Jonathan P. Fadok, Fumitaka Osakada, Dieter Saur, Benjamin F. Grewe, Mark J. Schnitzer, Edward M. Callaway, Andreas Lüthi
Publication: Cell
Date: October 20, 2016
Link to article: https://media.inscopix.com/cs/c/?cta_guid=7dd90e1a-9551-4dba-a6bd-42971df231d4&…


Memories about sensory experiences are tightly linked to the context in which they were formed. Memory contextualization is fundamental for the selection of appropriate behavioral reactions needed for survival, yet the underlying neuronal circuits are poorly understood. By combining trans-synaptic viral tracing and optogenetic manipulation, we found that the ventral hippocampus (vHC) and the amygdala, two key brain structures encoding context and emotional experiences, interact via multiple parallel pathways.

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