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Zolpidem reduces hippocampal neuronal activity in freely behaving mice: a large scale calcium imaging study with miniaturized fluorescence microscope


Authors: Tamara Berdyyeva, Stephani Otte, Leah Aluisio,Yaniv Ziv, Laurie D. Burns, Christine Dugovic, Sujin Yun, Kunal K. Ghosh, Mark J. Schnitzer, Timothy Lovenberg, Pascal Bonaventure
Publication: PLOS ONE
Date: November 5, 2014
Link to article: https://media.inscopix.com/cs/c/?cta_guid=62499320-086f-47c9-b34c-b126a5b59bea&…


Therapeutic drugs for cognitive and psychiatric disorders are often characterized by their molecular mechanism of action. Here we demonstrate a new approach to elucidate drug action on large-scale neuronal activity by tracking somatic calcium dynamics in hundreds of CA1 hippocampal neurons of pharmacologically manipulated behaving mice. We used an adeno-associated viral vector to express the calcium sensor GCaMP3 in CA1 pyramidal cells under control of the CaMKII promoter and a miniaturized microscope to observe cellular dynamics.

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