Prefrontal cortex (PFC) Archives

Long-range inhibition synchronizes and updates prefrontal task activity

Kathleen K. A. Cho et al.
Nature | April 26, 2023
Changes in patterns of activity within the medial prefrontal cortex enable rodents,non-human primates and humans to update their behaviour to adapt to changes in the environment—for example, during cognitive tasks....

Sex differences in neural representations of social and nonsocial reward in the medial prefrontal cortex

Jennifer Isaac et al.
bioRxiv | March 10, 2023
The reinforcing nature of social interactions is necessary for the maintenance of appropriate social behavior. However, the neural substrates underlying social reward and whether these are shared with competing...

Hypothalamic neurons that mirror aggression

Taehong Yang et al.
Cell | February 15, 2023
Social interactions require awareness and understanding of the behavior of others. Mirror neurons, cells representing an action by self and others, have been proposed to be integral to the cognitive substrates that...

Longitudinal Monitoring of Prefrontal Cortical Ensemble Dynamics Reveals New Insights into Stress Habituation

Sachin Patel et al.
Neurobiology of Stress | September 3, 2022
The prefrontal cortex is highly susceptible to the detrimental effects of stress and has been implicated in the pathogenesis of stress-related psychiatric disorders. It is not well understood, however, how stress is...

Pattern decorrelation in the mouse medial prefrontal cortex enables social preference and requires MeCP2

Pan Xu et al.
Nature Communications | July 6, 2022
Sociability is crucial for survival, whereas social avoidance is a feature of disorders such as Rett syndrome, which is caused by loss-of-function mutations in MECP2. To understand how a preference for social...

Neural circuit pathology driven by Shank3 mutation disrupts social behaviors

Sunwhi Kim et al.
Cell Reports | June 7, 2022
Dysfunctional sociability is a core symptom in autism spectrum disorder (ASD) that may arise from neural-network dysconnectivity between multiple brain regions. However, pathogenic neural-network mechanisms underlying...

Top-down control of hippocampal signal-to-noise by prefrontal long-range inhibition

Ruchi Malik et al.
Cell | April 28, 2022
Prefrontal cortex (PFC) is postulated to exert “top-down control” on information processing throughout the brain to promote specific behaviors. However, pathways mediating top-down control remain poorly understood....

Disrupted population coding in the prefrontal cortex underlies pain aversion

Anna Li et al.
Cell Reports | November 9, 2021
The prefrontal cortex (PFC) regulates a wide range of sensory experiences. Chronic pain is known to impair normal neural response, leading to enhanced aversion. However, it remains unknown how nociceptive responses in...

Differential encoding in prefrontal cortex projection neuron classes across cognitive tasks

Jan H. Lui et al.
Cell | December 17, 2020
Single-cell transcriptomics has been widely applied to classify neurons in the mammalian brain, while systems neuroscience has historically analyzed the encoding properties of cortical neurons without considering cell...

Dysregulation of the Synaptic Cytoskeleton in the PFC Drives Neural Circuit Pathology, Leading to Social Dysfunction

Il Hwan Kim et al.
Cell Reports | July 28, 2020
Psychiatric disorders are highly heritable pathologies of altered neural circuit functioning. How genetic mutations lead to specific neural circuit abnormalities underlying behavioral disruptions, however, remains...

Precision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicator

Or A. Shemesh et al.
Neuron | June 26, 2020
Methods for one-photon fluorescent imaging of calcium dynamics can capture the activity of hundreds of neurons across large fields of view at a low equipment complexity and cost. In contrast to two-photon methods,...

Soma-Targeted Imaging of Neural Circuits by Ribosome Tethering

Yiming Chen et al.
Neuron | June 22, 2020
Neuroscience relies on techniques for imaging the structure and dynamics of neural circuits, but the cell bodies of individual neurons are often obscured by overlapping fluorescence from axons and dendrites in...

Inscopix Publications

Publication Category: Prefrontal cortex (PFC)