Action movement Archives - Page 2 of 2

A Distributed Neural Code in the Dentate Gyrus and in CA1

Fabio Stefanini et al.
Neuron | June 9, 2020
Neurons are often considered specialized functional units that encode a single variable. However, many neurons are observed to respond to a mix of disparate sensory, cognitive, and behavioral variables. For such...

Action representation in the mouse parieto-frontal network

Tuce Tombaz et al.
Scientific Reports | March 27, 2020
The posterior parietal cortex (PPC) and frontal motor areas comprise a cortical network supporting goal-directed behaviour, with functions including sensorimotor transformations and decision making. In primates, this...

Role of spontaneous and sensory orexin network dynamics in rapid locomotion initiation

Mahesh M. Karnani et al.
Progress In Neurotechnology | February 11, 2020
Appropriate motor control is critical for normal life, and requires hypothalamic hypocretin/orexin neurons (HONs). HONs are slowly regulated by nutrients, but also display rapid (subsecond) activity fluctuations in...

Calcium Transient Dynamics of Neural Ensembles in the Primary Motor Cortex of Naturally Behaving Monkeys

Takahiro Kondo et al.
Cell Reports | August 21, 2018
To understand brain circuits of cognitive behaviors under natural conditions, we developed techniques for imaging neuronal activities from large neuronal populations in the deep layer cortex of the naturally behaving...

Diametric neural ensemble dynamics in parkinsonian and dyskinetic states

Jones G. Parker et al.
Nature | May 2, 2018
Loss of dopamine in Parkinson’s disease is hypothesized to impede movement by inducing hypo- and hyperactivity in striatal spiny projection neurons (SPNs) of the direct (dSPNs) and indirect (iSPNs) pathways in the...

Fast-Spiking Interneurons Supply Feedforward Control of Bursting, Calcium, and Plasticity for Efficient Learning

Scott F. Owen et al.
Cell | February 8, 2018
Fast-spiking interneurons (FSIs) are a prominent class of forebrain GABAergic cells implicated in two seemingly independent network functions: gain control and network plasticity. Little is known, however, about how...

Dopamine neuron activity before action initiation gates and invigorates future movements

Joaquim Alves da Silva et al.
Nature | January 31, 2018
Deciding when and whether to move is critical for survival. Loss of dopamine neurons (DANs) of the substantia nigra pars compacta (SNc) in patients with Parkinson’s disease causes deficits in movement initiation and...

The Spatiotemporal Organization of the Striatum Encodes Action Space

Andreas Klaus et al.
Neuron | August 30, 2017
Activity in striatal direct- and indirect-pathway spiny projection neurons (SPNs) is critical for proper movement. However, little is known about the spatiotemporal organization of this activity. We investigated the...

Delay activity of specific prefrontal interneuron subtypes modulates memory-guided behavior

Tsukasa Kamigaki et al.
Nature Neuroscience | April 24, 2017
Memory-guided behavior requires maintenance of task-relevant information without sensory input, but the underlying circuit mechanism remains unclear. Calcium imaging in mice performing a delayed Go or No-Go task...

Decreasing striatopallidal pathway function enhances motivation by energizing the initiation of goal-directed action

Fernanda Carvalho Poyraz et al.
The Journal of Neuroscience | June 1, 2016
Altered dopamine D2 receptor (D2R) binding in the striatum has been associated with abnormal motivation in neuropsychiatric disorders, including schizophrenia. Here, we tested whether motivational deficits observed in...

Cell-type-specific activity in prefrontal cortex during goal-directed behavior

Lucas Pinto et al.
Neuron | February 7, 2015
The prefrontal cortex (PFC) plays a key role in controlling goal-directed behavior. Although a variety of task-related signals have been observed in the PFC, whether they are differentially encoded by various cell types...

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Publication Category: Action movement