Addiction and reward Archives - Page 2 of 2

Spatial organization of functional clusters representing reward and movement information in the striatal direct and indirect pathways

Jung Hwan Shin et al.
PNAS | October 14, 2020
To obtain insights into striatal neural processes underlying reward-based learning and movement control, we examined spatial organizations of striatal neurons related to movement and reward-based learning. For this, we...

Opposing Regulation of Cocaine Seeking by Glutamate and GABA Neurons in the Ventral Pallidum

Jasper A. Heinsbroek et al.
Cell Reports | February 11, 2020
Projections from the nucleus accumbens to the ventral pallidum (VP) regulate relapse in animal models of addiction. The VP contains GABAergic (VPGABA) and glutamatergic (VPGlu) neurons, and a subpopulation of GABAergic...

Generality and opponency of rostromedial tegmental (RMTg) roles in valence processing

Hao Li et al.
eLife | January 22, 2020
The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine (DA) neurons, has been hypothesized to be broadly activated by aversive stimuli. However, this encoding pattern has only been...

A cortical-brainstem circuit predicts and governs compulsive alcohol drinking

Cody A. Siciliano et al.
Science | November 22, 2019
What individual differences in neural activity predict the future escalation of alcohol drinking from casual to compulsive? The neurobiological mechanisms that gate the transition from moderate to compulsive drinking...

Increased Cocaine Motivation Is Associated with Degraded Spatial and Temporal Representations in IL-NAc Neurons

Courtney M. Cameron et al.
Neuron | May 14, 2019
Craving for cocaine progressively increases in cocaine users during drug-free periods, contributing to relapse. The projection from the infralimbic cortex to the nucleus accumbens shell (IL-NAc) is thought to inhibit...

Leveraging calcium imaging to illuminate circuit dysfunction in addiction

Cody A. Siciliano et al.
Alcohol | February 1, 2019
Alcohol and drug use can dysregulate neural circuit function to produce a wide range of neuropsychiatric disorders, including addiction. To understand the neural circuit computations that mediate behavior, and how...

Dopamine enhances signal-to-noise ratio in cortical-brainstem encoding of aversive stimuli

Caitlin M. Vander Weele et al.
Nature | November 7, 2018
Dopamine modulates medial prefrontal cortex (mPFC) activity to mediate diverse behavioural functions1,2; however, the precise circuit computations remain unknown. One potentially unifying model by which dopamine may...

Anxiety Cells in a Hippocampal-Hypothalamic Circuit

Jessica C. Jimenez et al.
Neuron | January 31, 2018
The hippocampus is traditionally thought to transmit contextual information to limbic structures where it acquires valence. Using freely moving calcium imaging and optogenetics, we show that while the dorsal CA1...

Reward-Predictive Neural Activities in Striatal Striosome Compartments

Tomohiko Yoshizawa et al.
eNeuro | January 29, 2018
The striatum has been shown to play a critical role in reward prediction. It is composed of two neurochemically and anatomically distinct compartments known as the striosomes and the matrix. The striosomes comprise only...

Dorsal-CA1 hippocampal neuronal ensembles encode nicotine-reward contextual associations

Li Xia et al.
Cell Reports | June 6, 2017
Natural and drug rewards increase the motivational valence of stimuli in the environment that, through Pavlovian learning mechanisms, become conditioned stimuli that directly motivate behavior in the absence of the...

Contemporary approaches to neural circuit manipulation and mapping: focus on reward and addiction

Benjamin T. Saunders et al.
Biological Sciences | September 19, 2015
Tying complex psychological processes to precisely defined neural circuits is a major goal of systems and behavioural neuroscience. This is critical for understanding adaptive behaviour, and also how neural systems are...

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Publication Category: Addiction and reward