Appetitive behaviors Archives

Negative feedback control of hypothalamic feeding circuits by the taste of food

Tara J. Aitken et al.
Neuron | August 16, 2024
The rewarding taste of food is critical for motivating animals to eat, but whether taste has a parallel function in promoting meal termination is not well understood. Here, we show that hunger-promoting agouti-related...

Genetically- and spatially-defined basolateral amygdala neurons control food consumption and social interaction

Hansol Lim et al.
Nature Communications | August 11, 2024
The basolateral amygdala (BLA) contains discrete neuronal circuits that integrate positive or negative emotional information and drive the appropriate innate and learned behaviors. Whether these circuits consist of...

GLP-1 increases preingestive satiation via hypothalamic circuits in mice and humans

Kyu Sik Kim et al.
Science | June 27, 2024
Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs) are effective antiobesity drugs. However, the precise central mechanisms of GLP-1RAs remain elusive. We administered GLP-1RAs to patients with obesity and...

GABAergic disinhibition from the BNST to PNOC^ARC neurons promotes HFD-induced hyperphagia

Tamara Sotelo-Hitschfeld et al.
Cell Reports | June 11, 2024
Activation of prepronociceptin (PNOC)-expressing neurons in the arcuate nucleus (ARC) promotes high-fat-diet (HFD)-induced hyperphagia. In turn, PNOCARC neurons can inhibit the anorexic response of proopiomelanocortin...

Dynamic representation of appetitive and aversive stimuli in nucleus accumbens shell D1- and D2-medium spiny neurons

Ana Verónica Domingues et al.
bioRxiv | February 23, 2024
The nucleus accumbens (NAc) is a key brain region for motivated behaviors, yet how distinct neuronal populations encode appetitive or aversive stimuli remains undetermined. Using microendoscopic calcium imaging, we...

Two parabrachial Cck neurons involved in the feedback control of thirst or salt appetite

Takashi Matsuda et al.
Cell Reports | December 28, 2023
Thirst and salt appetite are temporarily suppressed after water and salt ingestion, respectively, before absorption; however, the underlying neural mechanisms remain unclear. The parabrachial nucleus (PBN) is the relay...

Lateral hypothalamic proenkephalin neurons drive threat-induced overeating associated with a negative emotional state

In-Jee You et al.
Nature Communications | October 28, 2023
Psychological stressors, like the nearby presence of a predator, can be strong enough to induce physiological/hormonal alterations, leading to appetite changes. However, little is known about how threats can alter...

Binge Feeding Promotes Appetite via Modulating Olfactory Flavor Representation

Hung Lo et al.
bioRxiv | October 17, 2023
Binge eating commonly leads to overeating, but the exact mechanism is unclear. While it is known that experiencing flavor contributes to satiety, the interactions between flavor, feeding rate, and food intake remain...

Neuronal Ensembles in the Infralimbic Cortex Dynamically Process Distinct Aspects of Hedonic Value

Seth W. Hurley et al.
Journal of Neuroscience | October 10, 2023
Hedonic processing is critical for guiding appropriate behavior, and the infralimbic cortex (IL) is a key neural substrate associated with this function in rodents and humans. We used deep brain, in vivo calcium imaging...

Lateral hypothalamic leptin receptor neurons drive hunger-gated food-seeking and consummatory behaviours in male mice

Young Hee Lee et al.
Nature Communications | March 17, 2023
For survival, it is crucial for eating behaviours to be sequenced through two distinct seeking and consummatory phases. Heterogeneous lateral hypothalamus (LH) neurons are known to regulate motivated behaviours, yet...

Experience-dependent changes in affective valence of taste in male mice

Shun Hamada et al.
Molecular Brain | March 11, 2023
The study conducted by Hamada et al. utilized nVista in vivo calcium imaging to examine the responses of central amygdala (CeA) neurons to sweet, umami, and bitter tastants. This innovative approach provided insights...

Complementary lateral hypothalamic populations resist hunger pressure to balance nutritional and social needs

Anne Petzold et al.
Cell Metabolism | February 23, 2023
Animals continuously weigh hunger and thirst against competing needs, such as social contact and mating, according to state and opportunity. Yet neuronal mechanisms of sensing and ranking nutritional needs remain poorly...

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Publication Category: Appetitive behaviors