Disease & therapeutics Archives

Heterogeneous subpopulations of GABA_AR-responding neurons coexist across neuronal networks scales and developmental stages in health and disease

I. Colombi et al.
iScience | March 8, 2024
GABA is the main inhibitory neurotransmitter in adults. Depolarizing GABA responses have been well characterized at neuronal-population average level during typical neurodevelopment and partially in brain disorders....

Neural correlate of reduced respiratory chemosensitivity during chronic epilepsy

Amol M. Bhandare et al.
Frontiers in Cellular Neuroscience | December 20, 2023
While central autonomic, cardiac, and/or respiratory dysfunction underlies sudden unexpected death in epilepsy (SUDEP), the specific neural mechanisms that lead to SUDEP remain to be determined. In this study, we took...

Deep brain stimulation of thalamic nucleus reuniens promotes neuronal and cognitive resilience in an Alzheimer’s disease mouse model

Shiri Shoob et al.
Nature Communications | November 2, 2023
The mechanisms that confer cognitive resilience to Alzheimer’s Disease (AD) are not fully understood. Here, we describe a neural circuit mechanism underlying this resilience in a familial AD mouse model. In the...

Antipsychotic drug efficacy correlates with the modulation of D1 rather than D2 receptor-expressing striatal projection neurons

Seongsik Yun et al.
Nature Neuroscience | July 13, 2023
Elevated dopamine transmission in psychosis is assumed to unbalance striatal output through D1- and D2-receptor-expressing spiny-projection neurons (SPNs). Antipsychotic drugs are thought to re-balance this output by...

Long-range inhibition synchronizes and updates prefrontal task activity

Kathleen K. A. Cho et al.
Nature | April 26, 2023
Changes in patterns of activity within the medial prefrontal cortex enable rodents,non-human primates and humans to update their behaviour to adapt to changes in the environment—for example, during cognitive tasks....

A weakened recurrent circuit in the hippocampus of Rett syndrome mice disrupts long-term memory representations

Lingjie He et al.
Neuron | May 18, 2022
Successful recall of a contextual memory requires reactivating ensembles of hippocampal cells that were allocated during memory formation. Altering the ratio of excitation-to-inhibition (E/I) during memory retrieval can...

The impact of pitolisant, an H3 receptor antagonist/inverse agonist, on perirhinal cortex activity in individual neuron and neuronal population levels

Kyosuke Hirano et al.
Scientific Reports | May 12, 2022
Histamine is a neurotransmitter that modulates neuronal activity and regulates various brain functions. Histamine H3 receptor (H3R) antagonists/inverse agonists enhance its release in most brain regions, including the...

Targeted activation of midbrain neurons restores locomotor function in mouse models of parkinsonism

Débora Masini et al.
Nature Communications | January 26, 2022
The pedunculopontine nucleus (PPN) is a locomotor command area containing glutamatergic neurons that control locomotor initiation and maintenance. These motor actions are deficient in Parkinson’s disease (PD), where...

Identification of Sclareol As a Natural Neuroprotective Ca_v1.3-Antagonist Using Synthetic Parkinson-Mimetic Gene Circuits and Computer-Aided Drug Discovery

Hui Wang et al.
Advanced Science | January 18, 2022
Parkinson’s disease (PD) results from selective loss of substantia nigra dopaminergic (SNc DA) neurons, and is primarily caused by excessive activity-related Ca2+ oscillations. Although L-type voltage-gated...

Distinct patterns of abnormal lateral orbitofrontal cortex activity during compulsive grooming and reversal learning normalize after fluoxetine

Elizabeth E. Manning et al.
Biological Psychiatry | November 26, 2021
Patients with obsessive-compulsive disorder (OCD) display disrupted performance and abnormal lateral orbitofrontal cortex (LOFC) activity during reversal learning tasks, yet it is unknown whether compulsions and...

A versatile computational algorithm for time-series data analysis and machine-learning models

Taylor Chomiak et al.
npj Parkinson's Disease | November 9, 2021
Here we introduce Local Topological Recurrence Analysis (LoTRA), a simple computational approach for analyzing time-series data. Its versatility is elucidated using simulated data, Parkinsonian gait, and in vivo brain...

Novel Time-series Data Analysis Algorithm

Taylor Chomiak et al.
NPJ Parkinson's Disease | November 9, 2021
LoTRA- a versatile algorithm for analyzing time-series data

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Publication Category: Disease & therapeutics