Disease & therapeutics Archives - Page 2 of 2

Accumbens D2-MSN hyperactivity drives antipsychotic-induced behavioral supersensitivity

Anna Kruyer et al.
Molecular Psychiatry | August 4, 2021
Antipsychotic-induced dopamine supersensitivity, or behavioral supersensitivity, is a problematic consequence of long-term antipsychotic treatment characterized by the emergence of motor abnormalities, refractory...

The melanocortin-3 receptor is a pharmacological target for the regulation of anorexia

Patrick Sweeney et al.
Science Translational Medicine | April 21, 2021
The eating disorder anorexia nervosa is potentially fatal but also poorly understood. Sweeney et al. now show that AgRP (Agouti-related protein)–expressing neurons, previously linked to anorexic feeding behavior,...

Parabrachial nucleus circuit governs neuropathic pain-like behavior

Li Sun et al.
Nature Communications | November 25, 2020
The lateral parabrachial nucleus (LPBN) is known to relay noxious information to the amygdala for processing affective responses. However, it is unclear whether the LPBN actively processes neuropathic pain characterized...

Calcium imaging in freely-moving mice during electrical stimulation of deep brain structures

James K Trevathan et al.
Journal of Neural Engineering | September 11, 2020
After decades of study in humans and animal models, there remains a lack of consensus regarding how the action of electrical stimulation on neuronal and non-neuronal elements – e.g. neuropil, cell bodies, glial cells,...

Concussion increases CA1 activity during prolonged inactivity in a familiar environment

Shanti R. Tummala et al.
Experimental Neurology | August 17, 2020
Although hippocampal damage plays a key role in impairments after concussion, differences in hippocampal information processing during recovery are unknown. Micro-endoscopic calcium imaging was performed before and...

General anesthetics activate a potent central pain-suppression circuit in the amygdala

Thuy Hua et al.
Nature Neuroscience | May 18, 2020
General anesthesia (GA) can produce analgesia (loss of pain) independent of inducing loss of consciousness, but the underlying mechanisms remain unclear. We hypothesized that GA suppresses pain in part by activating...

Activity dynamics of amygdala GABAergic neurons during cataplexy of narcolepsy

Ying Sun et al.
eLife | August 14, 2019
Recent studies showed activation of the GABAergic neurons in the central nucleus of the amygdala (CeA) triggered cataplexy of sleep disorder narcolepsy. However, there is still no direct evidence on CeA GABAergic...

Central amygdala circuit dynamics underlying the benzodiazepine anxiolytic effect

et al.
Molecular Psychiatry | November 30, 2018
Benzodiazepines (BZDs) have been a standard treatment for anxiety disorders for decades, but the neuronal circuit interactions mediating their anxiolytic effect remain largely unknown. Here, we find that systemic BZDs...

Diametric neural ensemble dynamics in parkinsonian and dyskinetic states

Jones G. Parker et al.
Nature | May 2, 2018
Loss of dopamine in Parkinson’s disease is hypothesized to impede movement by inducing hypo- and hyperactivity in striatal spiny projection neurons (SPNs) of the direct (dSPNs) and indirect (iSPNs) pathways in the...

Direct imaging of hippocampal epileptiform calcium motifs following kainic acid administration in freely behaving mice

Tamara K. Berdyyeva et al.
Frontiers in Neuroscience | February 29, 2016
Prolonged exposure to abnormally high calcium concentrations is thought to be a core mechanism underlying hippocampal damage in epileptic patients; however, no prior study has characterized calcium activity during...

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