Fear and anxiety Archives - Inscopix, Inc.

Prefrontal cortical dynorphin peptidergic transmission constrains threat-driven behavioral and network states

Huikun Wang et al.
Neuron | April 12, 2024
Prefrontal cortical (PFC) circuits provide top-down control of threat reactivity. This includes ventromedial PFC (vmPFC) circuitry, which plays a role in suppressing fear-related behavioral states. Dynorphin (Dyn) has...

A role for the cerebellum in motor-triggered alleviation of anxiety

Xiao-Yang Zhang et al.
Neuron | April 3, 2024
Physical exercise is known to reduce anxiety, but the underlying brain mechanisms remain unclear. Here, we explore a hypothalamo-cerebello-amygdalar circuit that may mediate motor-dependent alleviation of anxiety. This...

A distinct cortical code for socially learned threat

Shana E. Silverstein et al.
Nature | February 7, 2024
Animals can learn about sources of danger while minimizing their own risk by observing how others respond to threats. However, the distinct neural mechanisms by which threats are learned through social observation...

Neuronal tuning to threat exposure remains stable in the mouse prefrontal cortex over multiple days

Ole Christian Sylte et al.
PLOS Biology | January 11, 2024
Intense threat elicits action in the form of active and passive coping. The medial prefrontal cortex (mPFC) executes top-level control over the selection of threat coping strategies, but the dynamics of mPFC activity...

Disynaptic specificity of serial information flow for conditioned fear

LÉMA Massi et al.
Science Advances | January 20, 2023
Memory encoding and retrieval rely on specific interactions across multiple brain areas. Although connections between individual brain areas have been extensively studied, the anatomical and functional specificity of...

Topographic representation of current and future threats in the mouse nociceptive amygdala

Anna J. Bowen et al.
Nature Communications | January 12, 2023
Adaptive behaviors arise from an integration of current sensory context and internal representations of past experiences. The central amygdala (CeA) is positioned as a key integrator of cognitive and affective signals,...

Persistent representation of the environment in the hippocampus

Kyogo S. Kobayashi et al.
Cell Reports | January 11, 2023
In the hippocampus, environmental changes elicit rearrangement of active neuronal ensembles or remapping of place cells. However, it remains elusive how the brain ensures a consistent representation of a certain...

CaV3.1 T-type calcium channels are important for spatial memory processing in the dorsal subiculum

Srdjan M. Joksimovic et al.
Neuropharmacology | December 29, 2022
The dorsal subiculum (dSub) is one of the key structures responsible for the formation of hippocampal memory traces but the contribution of individual ionic currents to its cognitive function is not well studied....

Longitudinal Monitoring of Prefrontal Cortical Ensemble Dynamics Reveals New Insights into Stress Habituation

Sachin Patel et al.
Neurobiology of Stress | September 3, 2022
The prefrontal cortex is highly susceptible to the detrimental effects of stress and has been implicated in the pathogenesis of stress-related psychiatric disorders. It is not well understood, however, how stress is...

Hippocampal-amygdala memory circuits govern experience-dependent observational fear

Joseph I. Terranova et al.
Neuron | February 8, 2022
The empathic ability to vicariously experience the other’s fearful situation, a process called observational fear (OF), is critical to survive in nature and function in society. OF can be facilitated by both prior...

Divergent brainstem opioidergic pathways that coordinate breathing with pain and emotions

Shijia Liu et al.
Neuron | December 17, 2021
Breathing can be heavily influenced by pain or internal emotional states, but the neural circuitry underlying this tight coordination is unknown. Here we report that Oprm1 (μ-opioid receptor)-expressing neurons in the...

Intercalated amygdala clusters orchestrate a switch in fear state

Kenta M. Hagihara et al.
Nature | May 26, 2021
Adaptive behaviour necessitates the formation of memories for fearful events, but also that these memories can be extinguished. Effective extinction prevents excessive and persistent reactions to perceived threat, as...

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Publication Category: Fear and anxiety