Fear and anxiety Archives

Genetically- and spatially-defined basolateral amygdala neurons control food consumption and social interaction

Hansol Lim et al.
bioRxiv | October 17, 2023
The basolateral amygdala (BLA) contains discrete neuronal circuits that integrate positive or negative emotional information and drive the appropriate innate and learned behaviors. Whether these circuits consist of...

Disynaptic specificity of serial information flow for conditioned fear

LÉMA Massi et al.
Science Advances | January 20, 2023
Memory encoding and retrieval rely on specific interactions across multiple brain areas. Although connections between individual brain areas have been extensively studied, the anatomical and functional specificity of...

Topographic representation of current and future threats in the mouse nociceptive amygdala

Anna J. Bowen et al.
Nature Communications | January 12, 2023
Adaptive behaviors arise from an integration of current sensory context and internal representations of past experiences. The central amygdala (CeA) is positioned as a key integrator of cognitive and affective signals,...

Persistent representation of the environment in the hippocampus

Kyogo S. Kobayashi et al.
Cell Reports | January 11, 2023
In the hippocampus, environmental changes elicit rearrangement of active neuronal ensembles or remapping of place cells. However, it remains elusive how the brain ensures a consistent representation of a certain...

CaV3.1 T-type calcium channels are important for spatial memory processing in the dorsal subiculum

Srdjan M. Joksimovic et al.
Neuropharmacology | December 29, 2022
The dorsal subiculum (dSub) is one of the key structures responsible for the formation of hippocampal memory traces but the contribution of individual ionic currents to its cognitive function is not well studied....

Longitudinal Monitoring of Prefrontal Cortical Ensemble Dynamics Reveals New Insights into Stress Habituation

Sachin Patel et al.
Neurobiology of Stress | September 3, 2022
The prefrontal cortex is highly susceptible to the detrimental effects of stress and has been implicated in the pathogenesis of stress-related psychiatric disorders. It is not well understood, however, how stress is...

Hippocampal-amygdala memory circuits govern experience-dependent observational fear

Joseph I. Terranova et al.
Neuron | February 8, 2022
The empathic ability to vicariously experience the other’s fearful situation, a process called observational fear (OF), is critical to survive in nature and function in society. OF can be facilitated by both prior...

Divergent brainstem opioidergic pathways that coordinate breathing with pain and emotions

Shijia Liu et al.
Neuron | December 17, 2021
Breathing can be heavily influenced by pain or internal emotional states, but the neural circuitry underlying this tight coordination is unknown. Here we report that Oprm1 (μ-opioid receptor)-expressing neurons in the...

Intercalated amygdala clusters orchestrate a switch in fear state

Kenta M. Hagihara et al.
Nature | May 26, 2021
Adaptive behaviour necessitates the formation of memories for fearful events, but also that these memories can be extinguished. Effective extinction prevents excessive and persistent reactions to perceived threat, as...

Remapping of Adult-Born Neuron Activity during Fear Memory Consolidation in Mice

Pablo Vergara et al.
International Journal of Molecular Sciences | March 12, 2021
The mammalian hippocampal dentate gyrus is a unique memory circuit in which a subset of neurons is continuously generated throughout the lifespan. Previous studies have shown that the dentate gyrus neuronal population...

Independent and distinct patterns of abnormal lateral orbitofrontal cortex activity during compulsive grooming and reversal learning normalize after fluoxetine

Elizabeth E. Manning et al.
Biological Psychiatry | March 3, 2021
Background Patients with obsessive-compulsive disorder (OCD) display disrupted performance and abnormal lateral orbitofrontal cortex (LOFC) activity during reversal learning tasks, yet it is unknown whether compulsions...

Stimulus-specific hypothalamic encoding of a persistent defensive state

Ann Kennedy et al.
Nature | September 16, 2020
Persistent neural activity in cortical, hippocampal, and motor networks has been described as mediating working memory for transiently encountered stimuli. Internal emotional states, such as fear, also persist following...

Inscopix Publications

Publication Category: Fear and anxiety