Fear and anxiety Archives - Page 2 of 4

Intercalated amygdala clusters orchestrate a switch in fear state

Kenta M. Hagihara et al.
Nature | May 26, 2021
Adaptive behaviour necessitates the formation of memories for fearful events, but also that these memories can be extinguished. Effective extinction prevents excessive and persistent reactions to perceived threat, as...

Remapping of Adult-Born Neuron Activity during Fear Memory Consolidation in Mice

Pablo Vergara et al.
International Journal of Molecular Sciences | March 12, 2021
The mammalian hippocampal dentate gyrus is a unique memory circuit in which a subset of neurons is continuously generated throughout the lifespan. Previous studies have shown that the dentate gyrus neuronal population...

Independent and distinct patterns of abnormal lateral orbitofrontal cortex activity during compulsive grooming and reversal learning normalize after fluoxetine

Elizabeth E. Manning et al.
Biological Psychiatry | March 3, 2021
Background Patients with obsessive-compulsive disorder (OCD) display disrupted performance and abnormal lateral orbitofrontal cortex (LOFC) activity during reversal learning tasks, yet it is unknown whether compulsions...

Stimulus-specific hypothalamic encoding of a persistent defensive state

Ann Kennedy et al.
Nature | September 16, 2020
Persistent neural activity in cortical, hippocampal, and motor networks has been described as mediating working memory for transiently encountered stimuli. Internal emotional states, such as fear, also persist following...

Contextual fear memory retrieval by correlated ensembles of ventral CA1 neurons

Jessica C. Jimenez et al.
Nature Communications | July 13, 2020
Ventral hippocampal CA1 (vCA1) projections to the amygdala are necessary for contextual fear memory. Here we used in vivo Ca2+ imaging in mice to assess the temporal dynamics by which ensembles of vCA1 neurons mediate...

Heterogeneous Habenular Neuronal Ensembles during Selection of Defensive Behaviors

Salvatore Lecca et al.
Cell Reports | June 9, 2020
Optimal selection of threat-driven defensive behaviors is paramount to an animal’s survival. The lateral habenula (LHb) is a key neuronal hub coordinating behavioral responses to aversive stimuli. Yet, how individual...

Molecularly Defined Hippocampal Inputs Regulate Population Dynamics in the Prelimbic Cortex to Suppress Context Fear Memory Retrieval

Henry L. Hallock et al.
Biological Psychiatry | April 28, 2020
Background Context fear memory dysregulation is a hallmark symptom of several neuropsychiatric disorders, including generalized anxiety disorder and posttraumatic stress disorder. The hippocampus (HC) and prelimbic...

Persistent Activation of Central Amygdala CRF Neurons Helps Drive the Immediate Fear Extinction Deficit

Yong S. Jo et al.
Nature Communications | January 22, 2020
Fear extinction is an active learning process whereby previously established conditioned responses to a conditioned stimulus are suppressed. Paradoxically, when extinction training is performed immediately following...

Amygdala Reward Neurons Form and Store Fear Extinction Memory

Xiangyu Zhang et al.
Neuron | January 14, 2020
The ability to extinguish conditioned fear memory is critical for adaptive control of fear response, and its impairment is a hallmark of emotional disorders like post-traumatic stress disorder (PTSD). Fear extinction is...

Endocannabinoid Signaling Collapse Mediates Stress-Induced Amygdalo-Cortical Strengthening

David J. Marcus et al.
Neuron | January 13, 2020
Functional coupling between the amygdala and the dorsomedial prefrontal cortex (dmPFC) has been implicated in the generation of negative affective states; however, the mechanisms by which stress increases amygdala-dmPFC...

Adaptive disinhibitory gating by VIP interneurons permits associative learning

Sabine Krabbe et al.
Nature Neuroscience | October 21, 2019
Learning drives behavioral adaptations necessary for survival. While plasticity of excitatory projection neurons during associative learning has been extensively studied, little is known about the contributions of local...

VIP interneurons contribute to avoidance behavior by regulating information flow across hippocampal-prefrontal networks

Anthony T. Lee et al.
Neuron | April 30, 2019
Inhibitory interneurons expressing vasoactive intestinal polypeptide (VIP) are known to disinhibit cortical neurons. However, it is unclear how disinhibition, occurring at the single-cell level, interacts with...

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Publication Category: Fear and anxiety