Learning and Memory Archives

Selective engagement of prefrontal VIP neurons in reversal learning

Jee Hyun Yi et al.
bioRxiv | April 5, 2024
To gain insights into neural mechanisms enabling behavioral adaptations to complex and multidimensional environmental dynamics, we examined roles of VIP neurons in mouse medial prefrontal cortex (mPFC) in probabilistic...

Parabrachial Calca neurons mediate second-order conditioning

Sekun Park et al.
bioRxiv | March 25, 2024
Learning to associate cues, both directly and indirectly, with biologically significant events is essential for survival. Second-order conditioning (SOC) involves forming an association between a previously reinforced...

Tuned geometries of hippocampal representations meet the computational demands of social memory

Lara M. Boyle et al.
Neuron | February 20, 2024
Social memory consists of two processes: the detection of familiar compared with novel conspecifics and the detailed recollection of past social episodes. We investigated the neural bases for these processes using...

Memory encoding and retrieval by retrosplenial parvalbumin interneurons are impaired in Alzheimer’s disease model mice

Kyerl Park et al.
Current Biology | January 22, 2024
Memory deficits in Alzheimer’s disease (AD) show a strong link with GABAergic interneuron dysfunctions. The ensemble dynamics of GABAergic interneurons represent memory encoding and retrieval, but how GABAergic...

Dynamic and selective engrams emerge with memory consolidation

Douglas Feitosa Tomé et al.
Nature Neuroscience | January 19, 2024
Episodic memories are encoded by experience-activated neuronal ensembles that remain necessary and sufficient for recall. However, the temporal evolution of memory engrams after initial encoding is unclear. In this...

Motor cortex somatostatin interneurons adaptively shape the structure of motor sequences

Jeong Oen Lee et al.
bioRxiv | November 29, 2023
The brain can flexibly reorganize motor sequence, or program, execution to efficiently reach positive outcomes. These behavioral adaptations are primarily driven by reinforcement learning, leading to structural and...

Functional alterations of the prefrontal circuit underlying cognitive aging in mice

Huee Ru Chong et al.
Nature Communications | November 9, 2023
Executive function is susceptible to aging. How aging impacts the circuit-level computations underlying executive function remains unclear. Using calcium imaging and optogenetic manipulation during memory-guided...

Divergent Recruitment of Developmentally-Defined Neuronal Ensembles Supports Memory Dynamics

Vilde A. Kveim et al.
bioRxiv | November 6, 2023
Memories are dynamic constructs whose properties change with time and experience. The biological mechanisms underpinning these dynamics remain elusive, particularly concerning how shifts in the composition of...

Emergence of preparatory dynamics in VIP interneurons during motor learning

Sergio Arroyo et al.
Cell Reports | July 18, 2023
Study by Sergio Arroyo et al, investigates vasointestinal peptide (VIP) and somatostatin (SST) interneurons in the mouse secondary motor cortex during the acquisition of a cue-based reach-to-grasp task. VIP interneurons...

Control of contextual memory through interneuronal a5-GABAA receptors

Mengwen Zhu et al.
PNAS Nexus | April 11, 2023
γ-Aminobutyric acid type A receptors that incorporate α5 subunits (α5-GABAARs) are highly enriched in the hippocampus and are strongly implicated in control of learning and memory. Receptors located on pyramidal...

Topographic representation of current and future threats in the mouse nociceptive amygdala

Anna J. Bowen et al.
Nature Communications | January 12, 2023
Adaptive behaviors arise from an integration of current sensory context and internal representations of past experiences. The central amygdala (CeA) is positioned as a key integrator of cognitive and affective signals,...

Persistent representation of the environment in the hippocampus

Kyogo S. Kobayashi et al.
Cell Reports | January 11, 2023
In the hippocampus, environmental changes elicit rearrangement of active neuronal ensembles or remapping of place cells. However, it remains elusive how the brain ensures a consistent representation of a certain...

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Publication Category: Learning and Memory