Learning and Memory Archives - Page 6 of 6

Neurons for hunger and thirst transmit a negative-valence teaching signal

J. Nicholas Betley et al.
Nature | April 27, 2016
Homeostasis is a biological principle for regulation of essential physiological parameters within a set range. Behavioural responses due to deviation from homeostasis are critical for survival, but motivational...

Hippocampal ensemble dynamics timestamp events in long-term memory

Alon Rubin et al.
eLife | December 18, 2015
The capacity to remember temporal relationships between different events is essential to episodic memory, but little is currently known about its underlying mechanisms. We performed time-lapse imaging of thousands of...

Entorhinal cortical ocean cells encode specific contexts and drive context-specific fear memory

Takashi Kitamura et al.
Neuron | September 23, 2015
Forming distinct representations and memories of multiple contexts and episodes is thought to be a crucial function of the hippocampal-entorhinal cortical network. The hippocampal dentate gyrus (DG) and CA3 are known to...

Distinct speed dependence of entorhinal island and ocean cells, including respective grid cells

Chen Sun et al.
PNAS | July 13, 2015
Entorhinal–hippocampal circuits in the mammalian brain are crucial for an animal’s spatial and episodic experience, but the neural basis for different spatial computations remain unknown. Medial entorhinal cortex...

Zolpidem reduces hippocampal neuronal activity in freely behaving mice: a large scale calcium imaging study with miniaturized fluorescence microscope

Tamara Berdyyeva et al.
PLOS ONE | November 5, 2014
Therapeutic drugs for cognitive and psychiatric disorders are often characterized by their molecular mechanism of action. Here we demonstrate a new approach to elucidate drug action on large-scale neuronal activity by...

Imaging neuronal populations in behaving rodents: paradigms for studying neural circuits underlying behavior in the mammalian cortex

Jerry L. Chen et al.
The Journal of Neuroscience | November 6, 2013
Understanding the neural correlates of behavior in the mammalian cortex requires measurements of activity in awake, behaving animals. Rodents have emerged as a powerful model for dissecting the cortical circuits...

Long-term dynamics of CA1 hippocampal place codes

Yaniv Ziv et al.
Nature Neuroscience | February 10, 2013
Using Ca2+ imaging in freely behaving mice that repeatedly explored a familiar environment, we tracked thousands of CA1 pyramidal cells’ place fields over weeks. Place coding was dynamic, as each day the ensemble...

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Publication Category: Learning and Memory