Other Archives - Inscopix, Inc.

Functional imaging of nine distinct neuronal populations under a miniscope in freely behaving animals

Mary L. Phillips et al.
bioRxiv | December 14, 2023
Head-mounted miniscopes have allowed for functional fluorescence imaging in freely moving animals. However, current capabilities of state-of-the-art technology can record only up to two, spectrally distinct...

Long-range inhibition synchronizes and updates prefrontal task activity

Kathleen K. A. Cho et al.
Nature | April 26, 2023
Changes in patterns of activity within the medial prefrontal cortex enable rodents,non-human primates and humans to update their behaviour to adapt to changes in the environment—for example, during cognitive tasks....

Identification of an essential spinoparabrachial pathway for mechanical itch

Xiangyu Ren et al.
Neuron | April 5, 2023
The study identified a specific population of neurons that transmit mechanical itch from the spinal cord to the parabrachial nucleus (PBN) in the brain, and separate populations of neurons in the PBN relay mechanical...

Oxytocin promotes prefrontal population activity via the PVN-PFC pathway to regulate pain

Yaling Liu et al.
Neuron | April 4, 2023
Liu et al. conducted a study on rats to investigate the neural mechanisms involved in pain processing and modulation. Using behavioral assays and calcium imaging techniques, they sought to understand how oxytocin...

A neural substrate of sex-dependent modulation of motivation

Julia Cox et al.
Nature Neuroscience | February 16, 2023
While there is emerging evidence of sex differences in decision-making behavior, the neural substrates that underlie such differences remain largely unknown. Here we demonstrate that in mice performing a value-based...

Hypothalamic neurons that mirror aggression

Taehong Yang et al.
Cell | February 15, 2023
Social interactions require awareness and understanding of the behavior of others. Mirror neurons, cells representing an action by self and others, have been proposed to be integral to the cognitive substrates that...

A neural substrate for negative affect dictates female parental behavior

Salvatore Lecca et al.
Neuron | February 1, 2023
Parental behaviors secure the well-being of newborns and concomitantly limit negative affective states in adults, which emerge when coping with neonatal distress becomes challenging. Whether negative-affect-related...

Fiber photometry in striatum reflects primarily nonsomatic changes in calcium

Alex A. Legaria et al.
Nature Neuroscience | August 30, 2022
Fiber photometry enables recording of population neuronal calcium dynamics in awake mice. While the popularity of fiber photometry has grown in recent years, it remains unclear whether photometry reflects changes in...

Single-cell activity and network properties of dorsal raphe nucleus serotonin neurons during emotionally salient behaviors

Grace E. Paquelet et al.
Neuron | June 13, 2022
The serotonin system modulates a wide variety of emotional behaviors and states, including reward processing, anxiety, and social interaction. To reveal the underlying patterns of neural activity, we visualized...

Top-down control of hippocampal signal-to-noise by prefrontal long-range inhibition

Ruchi Malik et al.
Cell | April 28, 2022
Prefrontal cortex (PFC) is postulated to exert “top-down control” on information processing throughout the brain to promote specific behaviors. However, pathways mediating top-down control remain poorly understood....

Bias-free estimation of information content in temporally sparse neuronal activity

Liron Sheintuch et al.
PLOS Computational Biology | February 11, 2022
Applying information theoretic measures to neuronal activity data enables the quantification of neuronal encoding quality. However, when the sample size is limited, a naïve estimation of the information content...

In vivo imaging of the GnRH pulse generator reveals a temporal order of neuronal activation and synchronization during each pulse

Aleisha M. Moore et al.
PNAS | February 8, 2022
A hypothalamic pulse generator located in the arcuate nucleus controls episodic release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) and is essential for reproduction. Recent evidence suggests...

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