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In vivo imaging of the GnRH pulse generator reveals a temporal order of neuronal activation and synchronization during each pulse

Aleisha M. Moore et al.
PNAS | February 8, 2022
A hypothalamic pulse generator located in the arcuate nucleus controls episodic release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) and is essential for reproduction. Recent evidence suggests...

Differential encoding in prefrontal cortex projection neuron classes across cognitive tasks

Jan H. Lui et al.
Cell | December 17, 2020
Single-cell transcriptomics has been widely applied to classify neurons in the mammalian brain, while systems neuroscience has historically analyzed the encoding properties of cortical neurons without considering cell...

The amygdala instructs insular feedback for affective learning

Dominic Kargl et al.
eLife | November 20, 2020
Affective responses depend on assigning value to environmental predictors of threat or reward. Neuroanatomically, this affective value is encoded at both cortical and subcortical levels. However, the purpose of this...

Precision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicator

Or A. Shemesh et al.
Neuron | June 26, 2020
Methods for one-photon fluorescent imaging of calcium dynamics can capture the activity of hundreds of neurons across large fields of view at a low equipment complexity and cost. In contrast to two-photon methods,...

Soma-Targeted Imaging of Neural Circuits by Ribosome Tethering

Yiming Chen et al.
Neuron | June 22, 2020
Neuroscience relies on techniques for imaging the structure and dynamics of neural circuits, but the cell bodies of individual neurons are often obscured by overlapping fluorescence from axons and dendrites in...

Ca2+ imaging of neurons in freely moving rats with automatic post hoc histological identification

Philip Anner et al.
Journal of Neuroscience Methods | May 11, 2020
Background: Cognitive neuroscientists aim to understand behavior often based on the underlying activity of individual neurons. Recently developed miniaturized epifluorescence microscopes allow recording of cellular...

VIP interneurons contribute to avoidance behavior by regulating information flow across hippocampal-prefrontal networks

Anthony T. Lee et al.
Neuron | April 30, 2019
Inhibitory interneurons expressing vasoactive intestinal polypeptide (VIP) are known to disinhibit cortical neurons. However, it is unclear how disinhibition, occurring at the single-cell level, interacts with...

Unsupervised discovery of temporal sequences in high-dimensional datasets, with applications to neuroscience

Emily L Mackevicius et al.
eLife | February 5, 2019
Identifying low-dimensional features that describe large-scale neural recordings is a major challenge in neuroscience. Repeated temporal patterns (sequences) are thought to be a salient feature of neural dynamics, but...

Activity Patterns in the Neuropil of Striatal Cholinergic Interneurons in Freely Moving Mice Represent Their Collective Spiking Dynamics

Rotem Rehani et al.
eNeuro | January 4, 2019
Cholinergic interneurons (CINs) are believed to form synchronous cell assemblies that modulate the striatal microcircuitry and possibly orchestrate local dopamine release. We expressed GCaMP6s, a genetically encoded...

Touch and Tactile Neuropathic Pain Sensitivity Are Set by Corticospinal Projections

Yuanyuan Liu et al.
Nature | September 12, 2018
Current models of somatosensory perception emphasize transmission from primary sensory neurons to the spinal cord and on to the brain1,2,3,4. Mental influence on perception is largely assumed to occur locally within the...

Simultaneous Optogenetics and Cellular Resolution Calcium Imaging During Active Behavior Using a Miniaturized Microscope

Alice M. Stamatakis et al.
Frontiers in Neuroscience | July 24, 2018
The ability to precisely monitor and manipulate neural circuits is essential to understand the brain. Advancements over the last decade in optical techniques such as calcium imaging and optogenetics have empowered...

MIN1PIPE: A Miniscope 1-Photon-Based Calcium Imaging Signal Extraction Pipeline

Jinghao Lu et al.
Cell Reports | June 19, 2018
In vivo calcium imaging using a 1-photon-based miniscope and a microendoscopic lens enables studies of neural activities in freely behaving animals. However, the high and fluctuating background, the inevitable movements...

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