Rhythms and sleep Archives

Immediate responses to ambient light in vivo reveal distinct subpopulations of suprachiasmatic VIP neurons

Anat Kahan et al.
iScience | September 8, 2023
The circadian rhythm pacemaker, the suprachiasmatic nucleus (SCN), mediates light entrainment via vasoactive intestinal peptide (VIP) neurons (SCNVIP). Yet, how these neurons uniquely respond and connect to...

Unilateral Optogenetic Stimulation of Lhx6 Neurons in the Zona Incerta Increases REM sleep

Aurelio Vidal-Ortiz et al.
Sleep | August 21, 2023
To determine how a waking brain falls asleep researchers have monitored and manipulated activity of neurons and glia in various brain regions. While imaging GABA neurons in the zona incerta (ZI) we found a subgroup that...

Arginine–vasopressin-expressing neurons in the murine suprachiasmatic nucleus exhibit a circadian rhythm in network coherence in vivo

Adam Stowie et al.
PNAS | January 19, 2023
The suprachiasmatic nucleus (SCN) is composed of functionally distinct subpopulations of GABAergic neurons which form a neural network responsible for synchronizing most physiological and behavioral circadian rhythms in...

Control of non-REM sleep by ventrolateral medulla glutamatergic neurons projecting to the preoptic area

Sasa Teng et al.
Nature Communications | August 12, 2022
Understanding the neural mechanisms underlying sleep state transitions is a fundamental goal of neurobiology and important for the development of new treatments for insomnia and other sleep disorders. Yet, brain...

Nested calcium dynamics support daily cell unity and diversity in the suprachiasmatic nuclei of free-behaving mice

Lama El Cheikh Hussein et al.
PNAS Nexus | July 11, 2022
The suprachiasmatic nuclei (SCN) of the anterior hypothalamus host the circadian pacemaker that synchronizes mammalian rhythms with the day-night cycle. SCN neurons are intrinsically rhythmic, thanks to a conserved...

A Role for Astroglial Calcium in Mammalian Sleep and Sleep Regulation

Ashley M. Ingiosi et al.
Current Biology | September 24, 2020
Mammalian sleep expression and regulation have historically been thought to reflect the activity of neurons. Changes in other brain cells (glia) across the sleep-wake cycle and their role in sleep regulation are...

REM sleep stabilizes hypothalamic representation of feeding behavior

Lukas T. Oesch et al.
PNAS | July 30, 2020
During rapid eye movement (REM) sleep, behavioral unresponsiveness contrasts strongly with intense brain-wide neural network dynamics. Yet, the physiological functions of this cellular activation remain unclear. Using...

Sparse Activity of Hippocampal Adult-Born Neurons during REM Sleep Is Necessary for Memory Consolidation

Deependra Kumar et al.
Neuron | June 4, 2020
The occurrence of dreaming during rapid eye movement (REM) sleep prompts interest in the role of REM sleep in hippocampal-dependent episodic memory. Within the mammalian hippocampus, the dentate gyrus (DG) has the...

Control of Non-REM Sleep by Midbrain Neurotensinergic Neurons

Peng Zhong et al.
Neuron | September 30, 2019
The periaqueductal gray (PAG) in the midbrain is known to coordinate behavioral and autonomic responses to threat and injury through its descending projections to the brainstem. Here, we show that neurotensin...

REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories

Shuntaro Izawa et al.
Science | September 20, 2019
The neural mechanisms underlying memory regulation during sleep are not yet fully understood. We found that melanin concentrating hormone–producing neurons (MCH neurons) in the hypothalamus actively contribute to...

Activity dynamics of amygdala GABAergic neurons during cataplexy of narcolepsy

Ying Sun et al.
eLife | August 14, 2019
Recent studies showed activation of the GABAergic neurons in the central nucleus of the amygdala (CeA) triggered cataplexy of sleep disorder narcolepsy. However, there is still no direct evidence on CeA GABAergic...

A Rare Mutation of β1-Adrenergic Receptor Affects Sleep/Wake Behaviors

Guangsen Shi et al.
Neuron | May 28, 2019
Sleep is crucial for our survival, and many diseases are linked to long-term poor sleep quality. Before we can use sleep to enhance our health and performance and alleviate diseases associated with poor sleep, a greater...

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Publication Category: Rhythms and sleep