Rhythms and sleep Archives - Page 2 of 2

A Rare Mutation of β1-Adrenergic Receptor Affects Sleep/Wake Behaviors

Guangsen Shi et al.
Neuron | May 28, 2019
Sleep is crucial for our survival, and many diseases are linked to long-term poor sleep quality. Before we can use sleep to enhance our health and performance and alleviate diseases associated with poor sleep, a greater...

Dynamic network activation of hypothalamic MCH neurons in REM sleep and exploratory behavior

Carlos Blanco-Centurion et al.
J Neuroscience | April 29, 2019
Most brain neurons are active in waking, but hypothalamic neurons that synthesize the neuropeptide melanin-concentrating hormone (MCH) are claimed to be active only during sleep, particularly REM sleep. Here we use...

Cholinergic modulation of hippocampal calcium activity across the sleep-wake cycle

Heng Zhou et al.
eLife | March 7, 2019
Calcium is a critical second messenger in neurons that contributes to learning and memory, but how the coordination of action potentials of neuronal ensembles with the hippocampal local field potential (LFP) is...

GABA and glutamate neurons in the VTA regulate sleep and wakefulness

Xiao Yu et al.
Nature Neuroscience | December 17, 2018
We screened for novel circuits in the mouse brain that promote wakefulness. Chemogenetic activation experiments and electroencephalogram recordings pointed to glutamatergic/nitrergic (NOS1) and GABAergic neurons in the...

A Hypothalamic Switch for REM and Non-REM Sleep

Kai-Siang Chen et al.
Neuron | February 22, 2018
Rapid eye movement (REM) and non-REM (NREM) sleep are controlled by specific neuronal circuits. Here we show that galanin-expressing GABAergic neurons in the dorsomedial hypothalamus (DMH) comprise separate...

Regulation of REM and Non-REM Sleep by Periaqueductal GABAergic Neurons

Franz Weber et al.
Nature Communications | January 24, 2018
Mammalian sleep consists of distinct rapid eye movement (REM) and non-REM (NREM) states. The midbrain region ventrolateral periaqueductal gray (vlPAG) is known to be important for gating REM sleep, but the underlying...

Circuit-based interrogation of sleep control

Franz Weber et al.
Nature | October 5, 2016
Sleep is a fundamental biological process observed widely in the animal kingdom, but the neural circuits generating sleep remain poorly understood. Understanding the brain mechanisms controlling sleep requires the...

Calcium imaging of sleep–wake related neuronal activity in the dorsal pons

Julia Cox et al.
Nature Communications | February 25, 2016
The dorsal pons has long been implicated in the generation of rapid eye movement (REM) sleep, but the underlying circuit mechanisms remain poorly understood. Using cell-type-specific microendoscopic Ca2+ imaging in and...

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