nVue Archives - Inscopix, Inc.

Harnessing Miniscope Imaging in Freely Moving Animals to Unveil Migraine Pathophysiology and Validate Novel Therapeutic Strategies

Caroline Degel et al.
Synapse | November 20, 2024
Migraine is a debilitating neurological disorder that affects millions worldwide. Elucidating its underlying mechanisms is crucial for developing effective therapeutic interventions. In this editorial, we discuss the...

Long-term optical imaging of the spinal cord in awake behaving mice

Biafra Ahanonu et al.
Nature Methods | November 12, 2024
Advances in optical imaging and fluorescent biosensors enable study of the spatiotemporal and long-term neural dynamics in the brain of awake animals. However, methodological difficulties and fibrosis limit similar...

Divergent Recruitment of Developmentally-Defined Neuronal Ensembles Supports Memory Dynamics

Vilde A. Kveim et al.
Science | August 16, 2024
Memories are dynamic constructs whose properties change with time and experience. The biological mechanisms underpinning these dynamics remain elusive, particularly concerning how shifts in the composition of...

Lactate biosensors for spectrally and spatially multiplexed fluorescence imaging

Yusuke Nasu et al.
Nature Communications | October 27, 2023
l-Lactate is increasingly appreciated as a key metabolite and signaling molecule in mammals. However, investigations of the inter- and intra-cellular dynamics of l-lactate are currently hampered by the limited selection...

Dual color miniscope imaging of microvessels and neuronal activity in the hippocampus CA1 region of freely moving mice following alcohol administration

Kelsey North et al.
American Journal of Physiology | October 23, 2023
Moderate-to-heavy episodic (“binge”) drinking is the most common form of alcohol consumption in the United States. Alcohol at binge drinking concentrations reduces brain artery diameter in vivo and in vitro...

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