← Return to the Publications page

Inscopix Publications

Decreasing striatopallidal pathway function enhances motivation by energizing the initiation of goal-directed action


Authors: Fernanda Carvalho Poyraz, Eva Holzner, Matthew R. Bailey, Jozsef Meszaros, Lindsay Kenney, Mazen A. Kheirbek, Peter D. Balsam and Christoph Kellendonk
Publication: The Journal of Neuroscience
Date: June 1, 2016
Link to article: https://media.inscopix.com/cs/c/?cta_guid=f916c268-8463-4794-9cc3-3082961f8b5c&…


Altered dopamine D2 receptor (D2R) binding in the striatum has been associated with abnormal motivation in neuropsychiatric disorders, including schizophrenia. Here, we tested whether motivational deficits observed in mice with upregulated D2Rs (D2R-OEdev mice) are reversed by decreasing function of the striatopallidal “no-go” pathway. To this end, we expressed the Gαi-coupled designer receptor hM4D in adult striatopallidal neurons and activated the receptor with clozapine-N-oxide (CNO).

Scroll to Top