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Authors: Natalia V. Barykina, Oksana M. Subach, Danila A. Doronin, Vladimir P. Sotskov, Marina A. Roshchina, Tatiana A. Kunitsyna, Aleksey Y. Malyshev, Ivan V. Smirnov, Asya M. Azieva, Ilya S. Sokolov, Kiryl D. Piatkevich, Mikhail S. Burtsev, Anna M. Varizhuk, Galina E. Pozmogova, Konstantin V. Anokhin, Fedor V. Subach, Grigori N. Enikolopov
Publication: Scientific Reports
Date: September 28, 2016
Link to article: https://www.nature.com/articles/srep34447?__hssc=91116613.15.1608871335500&__hs…
Abstract
Genetically encoded calcium indicators (GECIs) are mainly represented by two- or one-fluorophore-based sensors. One type of two-fluorophore-based sensor, carrying Opsanus troponin C (TnC) as the Ca2+-binding moiety, has two binding sites for calcium ions, providing a linear response to calcium ions. One-fluorophore-based sensors have four Ca2+-binding sites but are better suited for in vivo experiments.
