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Neurons for hunger and thirst transmit a negative-valence teaching signal

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Authors: J. Nicholas Betley, Shengjin Xu, Zhen Fang Huang Cao, Rong Gong, Christopher J. Magnus, Yang Yu, Scott M. Sternson
Publication: Nature
Published Date: April 27, 2016
Article Link: https://www.nature.com/articles/nature14416

Abstract

Homeostasis is a biological principle for regulation of essential physiological parameters within a set range. Behavioural responses due to deviation from homeostasis are critical for survival, but motivational processes engaged by physiological need states are incompletely understood. We examined motivational characteristics of two separate neuron populations that regulate energy and fluid homeostasis by using cell-type-specific activity manipulations in mice.

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