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Ventral CA1 neurons store social memory


Authors: Teruhiro Okuyama, Takashi Kitamura, Dheeraj S. Roy, Shigeyoshi Itohara, Susumu Tonegawa
Publication: Science
Date: September 30, 2016
Link to article: https://science.sciencemag.org/content/353/6307/1536?__hssc=91116613.16.1608871…


The medial temporal lobe, including the hippocampus, has been implicated in social memory. However, it remains unknown which parts of these brain regions and their circuits hold social memory. Here, we show that ventral hippocampal CA1 (vCA1) neurons of a mouse and their projections to nucleus accumbens (NAc) shell play a necessary and sufficient role in social memory. Both the proportion of activated vCA1 cells and the strength and stability of the responding cells are greater in response to a familiar mouse than to a previously unencountered mouse.

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