Mouse Archives - Page 2 of 22

Dopamine neuron activity encodes the length of upcoming contralateral movement sequences

Marcelo D. Mendonça et al.
Current Biology | February 19, 2024
Dopaminergic neurons (DANs) in the substantia nigra pars compacta (SNc) have been related to movement speed, and loss of these neurons leads to bradykinesia in Parkinson’s disease (PD). However, other aspects of...

Basal ganglia–spinal cord pathway that commands locomotor gait asymmetries in mice

Jared M. Cregg et al.
Nature Neuroscience | February 12, 2024
The basal ganglia are essential for executing motor actions. How the basal ganglia engage spinal motor networks has remained elusive. Medullary Chx10 gigantocellular (Gi) neurons are required for turning gait programs,...

A distinct cortical code for socially learned threat

Shana E. Silverstein et al.
Nature | February 7, 2024
Animals can learn about sources of danger while minimizing their own risk by observing how others respond to threats. However, the distinct neural mechanisms by which threats are learned through social observation...

Psilocybin-enhanced fear extinction linked to bidirectional modulation of cortical ensembles

Sophie A. Rogers et al.
bioRxiv | February 4, 2024
The serotonin 2 receptor (5HT2R) agonist psilocybin has demonstrated rapid and long-lasting efficacy across neuropsychiatric disorders characterized by cognitive inflexibility. Psilocybin may accomplish this by inducing...

Somatosensory cortex and central amygdala regulate neuropathic pain-mediated peripheral immune response via vagal projections to the spleen

Xia Zhu et al.
Nature Neuroscience | January 30, 2024
Pain involves neuroimmune crosstalk, but the mechanisms of this remain unclear. Here we showed that the splenic T helper 2 (TH2) immune cell response is differentially regulated in male mice with acute versus chronic...

Differential contribution of distinct neuronal populations to danger representations

Ana Paula Menegolla et al.
bioRxiv | January 24, 2024
The recognition of specific stimuli and contexts in dangerous situations determines the expression of behaviors needed to appropriately cope with each threatening encounter. Moreover, the detection of common features...

Memory encoding and retrieval by retrosplenial parvalbumin interneurons are impaired in Alzheimer’s disease model mice

Kyerl Park et al.
Current Biology | January 22, 2024
Memory deficits in Alzheimer’s disease (AD) show a strong link with GABAergic interneuron dysfunctions. The ensemble dynamics of GABAergic interneurons represent memory encoding and retrieval, but how GABAergic...

Dynamic and selective engrams emerge with memory consolidation

Douglas Feitosa Tomé et al.
Nature Neuroscience | January 19, 2024
Episodic memories are encoded by experience-activated neuronal ensembles that remain necessary and sufficient for recall. However, the temporal evolution of memory engrams after initial encoding is unclear. In this...

Neuronal tuning to threat exposure remains stable in the mouse prefrontal cortex over multiple days

Ole Christian Sylte et al.
PLOS Biology | January 11, 2024
Intense threat elicits action in the form of active and passive coping. The medial prefrontal cortex (mPFC) executes top-level control over the selection of threat coping strategies, but the dynamics of mPFC activity...

Two parabrachial Cck neurons involved in the feedback control of thirst or salt appetite

Takashi Matsuda et al.
Cell Reports | December 28, 2023
Thirst and salt appetite are temporarily suppressed after water and salt ingestion, respectively, before absorption; however, the underlying neural mechanisms remain unclear. The parabrachial nucleus (PBN) is the relay...

Neural correlate of reduced respiratory chemosensitivity during chronic epilepsy

Amol M. Bhandare et al.
Frontiers in Cellular Neuroscience | December 20, 2023
While central autonomic, cardiac, and/or respiratory dysfunction underlies sudden unexpected death in epilepsy (SUDEP), the specific neural mechanisms that lead to SUDEP remain to be determined. In this study, we took...

Functional imaging of nine distinct neuronal populations under a miniscope in freely behaving animals

Mary L. Phillips et al.
bioRxiv | December 14, 2023
Head-mounted miniscopes have allowed for functional fluorescence imaging in freely moving animals. However, current capabilities of state-of-the-art technology can record only up to two, spectrally distinct...

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