Mouse Archives - Page 22 of 22

Neurons for hunger and thirst transmit a negative-valence teaching signal

J. Nicholas Betley et al.
Nature | April 27, 2016
Homeostasis is a biological principle for regulation of essential physiological parameters within a set range. Behavioural responses due to deviation from homeostasis are critical for survival, but motivational...

Direct imaging of hippocampal epileptiform calcium motifs following kainic acid administration in freely behaving mice

Tamara K. Berdyyeva et al.
Frontiers in Neuroscience | February 29, 2016
Prolonged exposure to abnormally high calcium concentrations is thought to be a core mechanism underlying hippocampal damage in epileptic patients; however, no prior study has characterized calcium activity during...

Calcium imaging of sleep–wake related neuronal activity in the dorsal pons

Julia Cox et al.
Nature Communications | February 25, 2016
The dorsal pons has long been implicated in the generation of rapid eye movement (REM) sleep, but the underlying circuit mechanisms remain poorly understood. Using cell-type-specific microendoscopic Ca2+ imaging in and...

Visualization of cortical, subcortical and deep brain neural circuit dynamics during naturalistic mammalian behavior with head-mounted microscopes and chronically implanted lenses

Shanna L Resendez et al.
Nature Protocols | February 25, 2016
Genetically encoded calcium indicators for visualizing dynamic cellular activity have greatly expanded our understanding of the brain. However, owing to the light-scattering properties of the brain, as well as the size...

Hippocampal ensemble dynamics timestamp events in long-term memory

Alon Rubin et al.
eLife | December 18, 2015
The capacity to remember temporal relationships between different events is essential to episodic memory, but little is currently known about its underlying mechanisms. We performed time-lapse imaging of thousands of...

Entorhinal cortical ocean cells encode specific contexts and drive context-specific fear memory

Takashi Kitamura et al.
Neuron | September 23, 2015
Forming distinct representations and memories of multiple contexts and episodes is thought to be a crucial function of the hippocampal-entorhinal cortical network. The hippocampal dentate gyrus (DG) and CA3 are known to...

Distinct speed dependence of entorhinal island and ocean cells, including respective grid cells

Chen Sun et al.
PNAS | July 13, 2015
Entorhinal–hippocampal circuits in the mammalian brain are crucial for an animal’s spatial and episodic experience, but the neural basis for different spatial computations remain unknown. Medial entorhinal cortex...

Cell-type-specific activity in prefrontal cortex during goal-directed behavior

Lucas Pinto et al.
Neuron | February 7, 2015
The prefrontal cortex (PFC) plays a key role in controlling goal-directed behavior. Although a variety of task-related signals have been observed in the PFC, whether they are differentially encoded by various cell types...

Visualizing hypothalamic network dynamics for appetitive and consummatory behaviors

Joshua H. Jennings et al.
Cell | January 29, 2015
Optimally orchestrating complex behavioral states, such as the pursuit and consumption of food, is critical for an organism’s survival. The lateral hypothalamus (LH) is a neuroanatomical region essential for...

Zolpidem reduces hippocampal neuronal activity in freely behaving mice: a large scale calcium imaging study with miniaturized fluorescence microscope

Tamara Berdyyeva et al.
PLOS ONE | November 5, 2014
Therapeutic drugs for cognitive and psychiatric disorders are often characterized by their molecular mechanism of action. Here we demonstrate a new approach to elucidate drug action on large-scale neuronal activity by...

Long-term dynamics of CA1 hippocampal place codes

Yaniv Ziv et al.
Nature Neuroscience | February 10, 2013
Using Ca2+ imaging in freely behaving mice that repeatedly explored a familiar environment, we tracked thousands of CA1 pyramidal cells’ place fields over weeks. Place coding was dynamic, as each day the ensemble...

Miniaturized integration of a fluorescence microscope

Kunal K Ghosh et al.
Nature Methods | September 11, 2011
The light microscope is traditionally an instrument of substantial size and expense. Its miniaturized integration would enable many new applications based on mass-producible, tiny microscopes. Key prospective usages...

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