Mouse Archives - Page 21 of 23

The Spatiotemporal Organization of the Striatum Encodes Action Space

Andreas Klaus et al.
Neuron | August 30, 2017
Activity in striatal direct- and indirect-pathway spiny projection neurons (SPNs) is critical for proper movement. However, little is known about the spatiotemporal organization of this activity. We investigated the...

Central amygdala circuits modulate food consumption through a positive-valence mechanism

Amelia M Douglass et al.
Nature Neuroscience | August 21, 2017
The complex behaviors underlying reward seeking and consumption are integral to organism survival. The hypothalamus and mesolimbic dopamine system are key mediators of these behaviors, yet regulation of appetitive and...

Skin suturing and cortical surface viral infusion improves imaging of neuronal ensemble activity with head-mounted miniature microscopes

Xinjian Li et al.
Journal of Neuroscience Methods | August 19, 2017
In vivo optical imaging of neural activity provides important insights into brain functions at the single-cell level. Cranial windows and virally delivered calcium indicators are commonly used for imaging cortical...

Distinct Neural Circuits for the Formation and Retrieval of Episodic Memories

Dheeraj S. Roy et al.
Cell | August 17, 2017
The formation and retrieval of a memory is thought to be accomplished by activation and reactivation, respectively, of the memory-holding cells (engram cells) by a common set of neural circuits, but this hypothesis has...

Multi-layer cortical calcium imaging in freely moving mice with prism probes and miniaturized fluorescence microscopy

Srishti Gulati et al.
JoVE | June 13, 2017
In vivo circuit and cellular level functional imaging is a critical tool for understanding the brain in action. High resolution imaging of mouse cortical neurons with two-photon microscopy has provided unique insights...

Dorsal-CA1 hippocampal neuronal ensembles encode nicotine-reward contextual associations

Li Xia et al.
Cell Reports | June 6, 2017
Natural and drug rewards increase the motivational valence of stimuli in the environment that, through Pavlovian learning mechanisms, become conditioned stimuli that directly motivate behavior in the absence of the...

Delay activity of specific prefrontal interneuron subtypes modulates memory-guided behavior

Tsukasa Kamigaki et al.
Nature Neuroscience | April 24, 2017
Memory-guided behavior requires maintenance of task-relevant information without sensory input, but the underlying circuit mechanism remains unclear. Calcium imaging in mice performing a delayed Go or No-Go task...

Engrams and circuits crucial for systems consolidation of a memory

Takashi Kitamura et al.
Science | April 7, 2017
Episodic memories initially require rapid synaptic plasticity within the hippocampus for their formation and are gradually consolidated in neocortical networks for permanent storage. However, the engrams and circuits...

Active dentate granule cells encode experience to promote the addition of adult-born hippocampal neurons

Gregory W. Kirschen et al.
The Journal of Neuroscience | April 3, 2017
The continuous addition of new dentate granule cells, exquisitely regulated by brain activity, renders the hippocampus plastic. However, how neural circuits encode experiences to impact the addition of adult-born...

Neural ensemble dynamics underlying a long-term associative memory

Benjamin F. Grewe et al.
Nature | March 22, 2017
The brain’s ability to associate different stimuli is vital for long-term memory, but how neural ensembles encode associative memories is unknown. Here we studied how cell ensembles in the basal and lateral amygdala...

Distinct hippocampal pathways mediate dissociable roles of context in memory retrieval

Chun Xu et al.
Cell | October 20, 2016
Memories about sensory experiences are tightly linked to the context in which they were formed. Memory contextualization is fundamental for the selection of appropriate behavioral reactions needed for survival, yet the...

Ventral CA1 neurons store social memory

Teruhiro Okuyama et al.
Science | September 30, 2016
The medial temporal lobe, including the hippocampus, has been implicated in social memory. However, it remains unknown which parts of these brain regions and their circuits hold social memory. Here, we show that ventral...

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