Amygdala Archives - Inscopix, Inc.

Heterogeneous plasticity of amygdala interneurons in associative learning and extinction

Natalia Favila et al.
bioRxiv | September 29, 2024
Neural circuits undergo experience-dependent plasticity to form long-lasting memories. Excitatory projection neurons are considered to be the primary neuronal substrate for memory acquisition and storage. However,...

Genetically- and spatially-defined basolateral amygdala neurons control food consumption and social interaction

Hansol Lim et al.
Nature Communications | August 11, 2024
The basolateral amygdala (BLA) contains discrete neuronal circuits that integrate positive or negative emotional information and drive the appropriate innate and learned behaviors. Whether these circuits consist of...

Remote automated delivery of mechanical stimuli coupled to brain recordings in behaving mice

Justin Burdge et al.
bioRxiv | May 7, 2024
The canonical framework for testing pain and mechanical sensitivity in rodents is manual delivery of stimuli to the paw. However, this approach can produce variability in results, requires significant training, and is...

Early life stress impairs VTA coordination of BLA network and behavioral states

Bradly T. Stone et al.
bioRxiv | September 17, 2023
Motivated behaviors, such as social interactions, are governed by the interplay between mesocorticolimbic structures, such as the ventral tegmental area (VTA), basolateral amygdala (BLA), and medial prefrontal cortex...

Adolescent stress impairs postpartum social behavior via anterior insula-prelimbic pathway in mice

Kyohei Kin et al.
Nature Communications | May 23, 2023
In a recent study by Kyohei Kin et al., the impact of adolescent psychosocial stress on postpartum social behavior was examined. Using innovative techniques such as optogenetics and in vivo microendoscopic calcium...

Identification of an essential spinoparabrachial pathway for mechanical itch

Xiangyu Ren et al.
Neuron | April 5, 2023
The study identified a specific population of neurons that transmit mechanical itch from the spinal cord to the parabrachial nucleus (PBN) in the brain, and separate populations of neurons in the PBN relay mechanical...

Experience-dependent changes in affective valence of taste in male mice

Shun Hamada et al.
Molecular Brain | March 11, 2023
The study conducted by Hamada et al. utilized nVista in vivo calcium imaging to examine the responses of central amygdala (CeA) neurons to sweet, umami, and bitter tastants. This innovative approach provided insights...

Disynaptic specificity of serial information flow for conditioned fear

LÉMA Massi et al.
Science Advances | January 20, 2023
Memory encoding and retrieval rely on specific interactions across multiple brain areas. Although connections between individual brain areas have been extensively studied, the anatomical and functional specificity of...

Topographic representation of current and future threats in the mouse nociceptive amygdala

Anna J. Bowen et al.
Nature Communications | January 12, 2023
Adaptive behaviors arise from an integration of current sensory context and internal representations of past experiences. The central amygdala (CeA) is positioned as a key integrator of cognitive and affective signals,...

Tripartite extended amygdala–basal ganglia CRH circuit drives locomotor activation and avoidance behavior

Simon Chang et al.
Science Advances | November 16, 2022
An adaptive stress response involves various mediators and circuits orchestrating a complex interplay of physiological, emotional, and behavioral adjustments. We identified a population of corticotropin-releasing...

Neural circuit pathology driven by Shank3 mutation disrupts social behaviors

Sunwhi Kim et al.
Cell Reports | June 7, 2022
Dysfunctional sociability is a core symptom in autism spectrum disorder (ASD) that may arise from neural-network dysconnectivity between multiple brain regions. However, pathogenic neural-network mechanisms underlying...

Encoding of environmental cues in central amygdala neurons during foraging

Marion Ponserre et al.
The Journal of Neuroscience | April 5, 2022
To successfully forage in an environment filled with rewards and threats, animals need to rely on familiar structures of their environment that signal food availability. The central amygdala (CeA) is known to mediate a...

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Publication Category: Amygdala