Amygdala Archives - Page 2 of 3

Divergent brainstem opioidergic pathways that coordinate breathing with pain and emotions

Shijia Liu et al.
Neuron | December 17, 2021
Breathing can be heavily influenced by pain or internal emotional states, but the neural circuitry underlying this tight coordination is unknown. Here we report that Oprm1 (μ-opioid receptor)-expressing neurons in the...

Intercalated amygdala clusters orchestrate a switch in fear state

Kenta M. Hagihara et al.
Nature | May 26, 2021
Adaptive behaviour necessitates the formation of memories for fearful events, but also that these memories can be extinguished. Effective extinction prevents excessive and persistent reactions to perceived threat, as...

State-dependent encoding of exploratory behaviour in the amygdala

Maria Sol Fustiñana et al.
Nature | March 3, 2021
The behaviour of an animal is determined by metabolic, emotional and social factors1,2. Depending on its state, an animal will focus on avoiding threats, foraging for food or on social interactions, and will display the...

The amygdala instructs insular feedback for affective learning

Dominic Kargl et al.
eLife | November 20, 2020
Affective responses depend on assigning value to environmental predictors of threat or reward. Neuroanatomically, this affective value is encoded at both cortical and subcortical levels. However, the purpose of this...

An Amygdala Circuit Mediates Experience-Dependent Momentary Arrests during Exploration

Paolo Botta et al.
Cell | October 7, 2020
Exploration of novel environments ensures survival and evolutionary fitness. It is expressed through exploratory bouts and arrests that change dynamically based on experience. Neural circuits mediating exploratory...

General anesthetics activate a potent central pain-suppression circuit in the amygdala

Thuy Hua et al.
Nature Neuroscience | May 18, 2020
General anesthesia (GA) can produce analgesia (loss of pain) independent of inducing loss of consciousness, but the underlying mechanisms remain unclear. We hypothesized that GA suppresses pain in part by activating...

Persistent Activation of Central Amygdala CRF Neurons Helps Drive the Immediate Fear Extinction Deficit

Yong S. Jo et al.
Nature Communications | January 22, 2020
Fear extinction is an active learning process whereby previously established conditioned responses to a conditioned stimulus are suppressed. Paradoxically, when extinction training is performed immediately following...

Amygdala Reward Neurons Form and Store Fear Extinction Memory

Xiangyu Zhang et al.
Neuron | January 14, 2020
The ability to extinguish conditioned fear memory is critical for adaptive control of fear response, and its impairment is a hallmark of emotional disorders like post-traumatic stress disorder (PTSD). Fear extinction is...

Adaptive disinhibitory gating by VIP interneurons permits associative learning

Sabine Krabbe et al.
Nature Neuroscience | October 21, 2019
Learning drives behavioral adaptations necessary for survival. While plasticity of excitatory projection neurons during associative learning has been extensively studied, little is known about the contributions of local...

Activity dynamics of amygdala GABAergic neurons during cataplexy of narcolepsy

Ying Sun et al.
eLife | August 14, 2019
Recent studies showed activation of the GABAergic neurons in the central nucleus of the amygdala (CeA) triggered cataplexy of sleep disorder narcolepsy. However, there is still no direct evidence on CeA GABAergic...

Amygdala ensembles encode behavioral states

Jan Gründemann et al.
Science | April 19, 2019
Internal states, including affective or homeostatic states, are important behavioral motivators. The amygdala regulates motivated behaviors, yet how distinct states are represented in amygdala circuits is unknown. By...

Divergent medial amygdala projections regulate approach–avoidance conflict behavior

Samara M. Miller et al.
Nature Neuroscience | February 25, 2019
Avoidance of innate threats is often in conflict with motivations to engage in exploratory approach behavior. The neural pathways that mediate this approach–avoidance conflict are not well resolved. Here we isolated a...

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Publication Category: Amygdala