Cortex Archives - Inscopix, Inc.

Psilocybin-enhanced fear extinction linked to bidirectional modulation of cortical ensembles

Sophie A. Rogers et al.
bioRxiv | February 4, 2024
The serotonin 2 receptor (5HT2R) agonist psilocybin has demonstrated rapid and long-lasting efficacy across neuropsychiatric disorders characterized by cognitive inflexibility. Psilocybin may accomplish this by inducing...

Somatosensory cortex and central amygdala regulate neuropathic pain-mediated peripheral immune response via vagal projections to the spleen

Xia Zhu et al.
Nature Neuroscience | January 30, 2024
Pain involves neuroimmune crosstalk, but the mechanisms of this remain unclear. Here we showed that the splenic T helper 2 (TH2) immune cell response is differentially regulated in male mice with acute versus chronic...

Memory encoding and retrieval by retrosplenial parvalbumin interneurons are impaired in Alzheimer’s disease model mice

Kyerl Park et al.
Current Biology | January 22, 2024
Memory deficits in Alzheimer’s disease (AD) show a strong link with GABAergic interneuron dysfunctions. The ensemble dynamics of GABAergic interneurons represent memory encoding and retrieval, but how GABAergic...

Motor cortex somatostatin interneurons adaptively shape the structure of motor sequences

Jeong Oen Lee et al.
bioRxiv | November 29, 2023
The brain can flexibly reorganize motor sequence, or program, execution to efficiently reach positive outcomes. These behavioral adaptations are primarily driven by reinforcement learning, leading to structural and...

Emergence of task-related spatiotemporal population dynamics in transplanted neurons

Harman Ghuman et al.
Nature Communications | November 11, 2023
Loss of nervous system tissue after severe brain injury is a main determinant of poor functional recovery. Cell transplantation is a promising method to restore lost tissue and function, yet it remains unclear if...

Binge Feeding Promotes Appetite via Modulating Olfactory Flavor Representation

Hung Lo et al.
bioRxiv | October 17, 2023
Binge eating commonly leads to overeating, but the exact mechanism is unclear. While it is known that experiencing flavor contributes to satiety, the interactions between flavor, feeding rate, and food intake remain...

Anterior cingulate cortex regulates pain catastrophizing-like behaviors in rats

Hyun Jung Jee et al.
Molecular Brain | October 13, 2023
Negative pain expectation including pain catastrophizing is a well-known clinical phenomenon whereby patients amplify the aversive value of a painful or oftentimes even a similar, non-painful stimulus. Mechanisms of...

Neuronal Ensembles in the Infralimbic Cortex Dynamically Process Distinct Aspects of Hedonic Value

Seth W. Hurley et al.
Journal of Neuroscience | October 10, 2023
Hedonic processing is critical for guiding appropriate behavior, and the infralimbic cortex (IL) is a key neural substrate associated with this function in rodents and humans. We used deep brain, in vivo calcium imaging...

Emergence of preparatory dynamics in VIP interneurons during motor learning

Sergio Arroyo et al.
Cell Reports | July 18, 2023
Study by Sergio Arroyo et al, investigates vasointestinal peptide (VIP) and somatostatin (SST) interneurons in the mouse secondary motor cortex during the acquisition of a cue-based reach-to-grasp task. VIP interneurons...

Self-organization of songbird neural sequences during social isolation

Emily L Mackevicius et al.
eLife | May 30, 2023
Emily L. Mackevicius et al., using the Inscopix nVista tool, investigated whether the formation of sequences in the high vocal center (HVC) of songbirds depends on prior exposure to a tutor song. They found that even in...

Adolescent stress impairs postpartum social behavior via anterior insula-prelimbic pathway in mice

Kyohei Kin et al.
Nature Communications | May 23, 2023
In a recent study by Kyohei Kin et al., the impact of adolescent psychosocial stress on postpartum social behavior was examined. Using innovative techniques such as optogenetics and in vivo microendoscopic calcium...

Identification of an essential spinoparabrachial pathway for mechanical itch

Xiangyu Ren et al.
Neuron | April 5, 2023
The study identified a specific population of neurons that transmit mechanical itch from the spinal cord to the parabrachial nucleus (PBN) in the brain, and separate populations of neurons in the PBN relay mechanical...

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