Cortex Archives - Page 5 of 5

Multi-layer cortical calcium imaging in freely moving mice with prism probes and miniaturized fluorescence microscopy

Srishti Gulati et al.
JoVE | June 13, 2017
In vivo circuit and cellular level functional imaging is a critical tool for understanding the brain in action. High resolution imaging of mouse cortical neurons with two-photon microscopy has provided unique insights...

Identification of a motor-to-auditory pathway important for vocal learning

Todd F Roberts et al.
Nature Neuroscience | May 15, 2017
Learning to vocalize depends on the ability to adaptively modify the temporal and spectral features of vocal elements. Neurons that convey motor-related signals to the auditory system are theorized to facilitate vocal...

Delay activity of specific prefrontal interneuron subtypes modulates memory-guided behavior

Tsukasa Kamigaki et al.
Nature Neuroscience | April 24, 2017
Memory-guided behavior requires maintenance of task-relevant information without sensory input, but the underlying circuit mechanism remains unclear. Calcium imaging in mice performing a delayed Go or No-Go task...

Engrams and circuits crucial for systems consolidation of a memory

Takashi Kitamura et al.
Science | April 7, 2017
Episodic memories initially require rapid synaptic plasticity within the hippocampus for their formation and are gradually consolidated in neocortical networks for permanent storage. However, the engrams and circuits...

A new design for a green calcium indicator with a smaller size and a reduced number of calcium-binding sites

Natalia V. Barykina et al.
Scientific Reports | September 28, 2016
Genetically encoded calcium indicators (GECIs) are mainly represented by two- or one-fluorophore-based sensors. One type of two-fluorophore-based sensor, carrying Opsanus troponin C (TnC) as the Ca2+-binding moiety, has...

Visualization of cortical, subcortical and deep brain neural circuit dynamics during naturalistic mammalian behavior with head-mounted microscopes and chronically implanted lenses

Shanna L Resendez et al.
Nature Protocols | February 25, 2016
Genetically encoded calcium indicators for visualizing dynamic cellular activity have greatly expanded our understanding of the brain. However, owing to the light-scattering properties of the brain, as well as the size...

Entorhinal cortical ocean cells encode specific contexts and drive context-specific fear memory

Takashi Kitamura et al.
Neuron | September 23, 2015
Forming distinct representations and memories of multiple contexts and episodes is thought to be a crucial function of the hippocampal-entorhinal cortical network. The hippocampal dentate gyrus (DG) and CA3 are known to...

Distinct speed dependence of entorhinal island and ocean cells, including respective grid cells

Chen Sun et al.
PNAS | July 13, 2015
Entorhinal–hippocampal circuits in the mammalian brain are crucial for an animal’s spatial and episodic experience, but the neural basis for different spatial computations remain unknown. Medial entorhinal cortex...

Mesoscopic patterns of neural activity support songbird cortical sequences

Jeffrey E. Markowitz et al.
PLOS Biology | June 3, 2015
Time-locked sequences of neural activity can be found throughout the vertebrate forebrain in various species and behavioral contexts. From “time cells” in the hippocampus of rodents to cortical activity controlling...

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