Cortex Archives - Page 4 of 5

VIP interneurons contribute to avoidance behavior by regulating information flow across hippocampal-prefrontal networks

Anthony T. Lee et al.
Neuron | April 30, 2019
Inhibitory interneurons expressing vasoactive intestinal polypeptide (VIP) are known to disinhibit cortical neurons. However, it is unclear how disinhibition, occurring at the single-cell level, interacts with...

Unsupervised discovery of temporal sequences in high-dimensional datasets, with applications to neuroscience

Emily L Mackevicius et al.
eLife | February 5, 2019
Identifying low-dimensional features that describe large-scale neural recordings is a major challenge in neuroscience. Repeated temporal patterns (sequences) are thought to be a salient feature of neural dynamics, but...

Touch and Tactile Neuropathic Pain Sensitivity Are Set by Corticospinal Projections

Yuanyuan Liu et al.
Nature | September 12, 2018
Current models of somatosensory perception emphasize transmission from primary sensory neurons to the spinal cord and on to the brain1,2,3,4. Mental influence on perception is largely assumed to occur locally within the...

Calcium Transient Dynamics of Neural Ensembles in the Primary Motor Cortex of Naturally Behaving Monkeys

Takahiro Kondo et al.
Cell Reports | August 21, 2018
To understand brain circuits of cognitive behaviors under natural conditions, we developed techniques for imaging neuronal activities from large neuronal populations in the deep layer cortex of the naturally behaving...

MIN1PIPE: A Miniscope 1-Photon-Based Calcium Imaging Signal Extraction Pipeline

Jinghao Lu et al.
Cell Reports | June 19, 2018
In vivo calcium imaging using a 1-photon-based miniscope and a microendoscopic lens enables studies of neural activities in freely behaving animals. However, the high and fluctuating background, the inevitable movements...

Combined Social and Spatial Coding in a Descending Projection from the Prefrontal Cortex

Malavika Murugan et al.
Cell | December 7, 2017
Social behaviors are crucial to all mammals. Although the prelimbic cortex (PL, part of medial prefrontal cortex) has been implicated in social behavior, it is not clear which neurons are relevant or how they...

Deconstruction of Corticospinal Circuits for Goal-Directed Motor Skills

et al.
Cell | September 21, 2017
Corticospinal neurons (CSNs) represent the direct cortical outputs to the spinal cord and play important roles in motor control across different species. However, their organizational principle remains unclear. By using...

Skin suturing and cortical surface viral infusion improves imaging of neuronal ensemble activity with head-mounted miniature microscopes

Xinjian Li et al.
Journal of Neuroscience Methods | August 19, 2017
In vivo optical imaging of neural activity provides important insights into brain functions at the single-cell level. Cranial windows and virally delivered calcium indicators are commonly used for imaging cortical...

Multi-layer cortical calcium imaging in freely moving mice with prism probes and miniaturized fluorescence microscopy

Srishti Gulati et al.
JoVE | June 13, 2017
In vivo circuit and cellular level functional imaging is a critical tool for understanding the brain in action. High resolution imaging of mouse cortical neurons with two-photon microscopy has provided unique insights...

Identification of a motor-to-auditory pathway important for vocal learning

Todd F Roberts et al.
Nature Neuroscience | May 15, 2017
Learning to vocalize depends on the ability to adaptively modify the temporal and spectral features of vocal elements. Neurons that convey motor-related signals to the auditory system are theorized to facilitate vocal...

Delay activity of specific prefrontal interneuron subtypes modulates memory-guided behavior

Tsukasa Kamigaki et al.
Nature Neuroscience | April 24, 2017
Memory-guided behavior requires maintenance of task-relevant information without sensory input, but the underlying circuit mechanism remains unclear. Calcium imaging in mice performing a delayed Go or No-Go task...

Engrams and circuits crucial for systems consolidation of a memory

Takashi Kitamura et al.
Science | April 7, 2017
Episodic memories initially require rapid synaptic plasticity within the hippocampus for their formation and are gradually consolidated in neocortical networks for permanent storage. However, the engrams and circuits...

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Publication Category: Cortex