Hippocampus Archives - Inscopix, Inc.

Heterogeneous subpopulations of GABA_AR-responding neurons coexist across neuronal networks scales and developmental stages in health and disease

I. Colombi et al.
iScience | March 8, 2024
GABA is the main inhibitory neurotransmitter in adults. Depolarizing GABA responses have been well characterized at neuronal-population average level during typical neurodevelopment and partially in brain disorders....

Tuned geometries of hippocampal representations meet the computational demands of social memory

Lara M. Boyle et al.
Neuron | February 20, 2024
Social memory consists of two processes: the detection of familiar compared with novel conspecifics and the detailed recollection of past social episodes. We investigated the neural bases for these processes using...

Dynamic and selective engrams emerge with memory consolidation

Douglas Feitosa Tomé et al.
Nature Neuroscience | January 19, 2024
Episodic memories are encoded by experience-activated neuronal ensembles that remain necessary and sufficient for recall. However, the temporal evolution of memory engrams after initial encoding is unclear. In this...

Divergent Recruitment of Developmentally-Defined Neuronal Ensembles Supports Memory Dynamics

Vilde A. Kveim et al.
bioRxiv | November 6, 2023
Memories are dynamic constructs whose properties change with time and experience. The biological mechanisms underpinning these dynamics remain elusive, particularly concerning how shifts in the composition of...

Deep brain stimulation of thalamic nucleus reuniens promotes neuronal and cognitive resilience in an Alzheimer’s disease mouse model

Shiri Shoob et al.
Nature Communications | November 2, 2023
The mechanisms that confer cognitive resilience to Alzheimer’s Disease (AD) are not fully understood. Here, we describe a neural circuit mechanism underlying this resilience in a familial AD mouse model. In the...

Dual color miniscope imaging of microvessels and neuronal activity in the hippocampus CA1 region of freely moving mice following alcohol administration

Kelsey North et al.
American Journal of Physiology | October 23, 2023
Moderate-to-heavy episodic (“binge”) drinking is the most common form of alcohol consumption in the United States. Alcohol at binge drinking concentrations reduces brain artery diameter in vivo and in vitro...

A neural mechanism for discriminating social threat from social safety

Pegah Kassraian et al.
bioRxiv | July 27, 2023
The ability to distinguish a threatening from non-threatening conspecific based on past experience is critical for adaptive social behaviors. Although recent progress has been made in identifying the neural circuits...

Active experience, not time, determines within-day representational drift in dorsal CA1

Dorgham Khatib et al.
Neuron | June 13, 2023
Memories of past events can be recalled long after the event, indicating stability. But new experiences are also integrated into existing memories, indicating plasticity. In the hippocampus, spatial representations are...

Control of contextual memory through interneuronal a5-GABAA receptors

Mengwen Zhu et al.
PNAS Nexus | April 11, 2023
γ-Aminobutyric acid type A receptors that incorporate α5 subunits (α5-GABAARs) are highly enriched in the hippocampus and are strongly implicated in control of learning and memory. Receptors located on pyramidal...

Persistent representation of the environment in the hippocampus

Kyogo S. Kobayashi et al.
Cell Reports | January 11, 2023
In the hippocampus, environmental changes elicit rearrangement of active neuronal ensembles or remapping of place cells. However, it remains elusive how the brain ensures a consistent representation of a certain...

Disruption of hippocampal neuronal circuit function depends upon behavioral state in the APP/PS1 mouse model of Alzheimer’s disease

Heng Zhou et al.
Scientific Reports | December 6, 2022
The Alzheimer’s disease-associated peptide amyloid-beta (Aβ) has been associated with neuronal hyperactivity under anesthesia, but clinical trials of anticonvulsants or neural system suppressors have, so far,...

Hippocampal representations of foraging trajectories depend upon spatial context

Wan-Chen Jiang et al.
Nature Neuroscience | November 28, 2022
Animals learn trajectories to rewards in both spatial, navigational contexts and relational, non-navigational contexts. Synchronous reactivation of hippocampal activity is thought to be critical for recall and...

Inscopix Publications

Publication Category: Hippocampus