Hippocampus Archives - Page 2 of 6

Hippocampal representations of foraging trajectories depend upon spatial context

Wan-Chen Jiang et al.
Nature Neuroscience | November 28, 2022
Animals learn trajectories to rewards in both spatial, navigational contexts and relational, non-navigational contexts. Synchronous reactivation of hippocampal activity is thought to be critical for recall and...

Forebrain Glucocorticoid Receptor Overexpression Alters Behavioral Encoding of Hippocampal CA1 Pyramidal Cells In Mice

Swapnil Gavade et al.
eNeuro | November 23, 2022
Glucocorticoid signaling influences hippocampal-dependent behavior and vulnerability to stress-related neuropsychiatric disorders. In mice, lifelong overexpression of glucocorticoid receptor (GR) in forebrain excitatory...

Exercise increases information content and affects long-term stability of hippocampal place codes

Yoav Rechavi et al.
Cell Reports | November 22, 2022
Physical exercise is known to augment brain functioning, improving memory and cognition. However, while some of the physiological effects of physical activity on the brain are known, little is known about its effects on...

Dose-dependent suppression of hippocampal contextual memory formation, place cells, and spatial engrams by the NMDAR antagonist (R)-CPP

Mengwen Zhu et al.
Neuropharmacology | August 14, 2022
We recently reported that the competitive NMDAR antagonist (R,S)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) does not suppress NMDAR-mediated field EPSPs (fEPSPNMDA) or long-term potentiation (LTP) in...

Multiple types of navigational information are independently encoded in the population activities of the dentate gyrus neurons

Tomoyuki Murano et al.
PNAS | August 5, 2022
The dentate gyrus (DG) plays critical roles in cognitive functions, such as learning, memory, and spatial coding, and its dysfunction is implicated in various neuropsychiatric disorders. However, it remains largely...

Noise correlations in neural ensemble activity limit the accuracy of hippocampal spatial representations

Omer Hazon et al.
Nature Communications | July 25, 2022
Neurons in the CA1 area of the mouse hippocampus encode the position of the animal in an environment. However, given the variability in individual neurons responses, the accuracy of this code is still poorly understood....

A weakened recurrent circuit in the hippocampus of Rett syndrome mice disrupts long-term memory representations

Lingjie He et al.
Neuron | May 18, 2022
Successful recall of a contextual memory requires reactivating ensembles of hippocampal cells that were allocated during memory formation. Altering the ratio of excitation-to-inhibition (E/I) during memory retrieval can...

Top-down control of hippocampal signal-to-noise by prefrontal long-range inhibition

Ruchi Malik et al.
Cell | April 28, 2022
Prefrontal cortex (PFC) is postulated to exert “top-down control” on information processing throughout the brain to promote specific behaviors. However, pathways mediating top-down control remain poorly understood....

A dentate gyrus-CA3 inhibitory circuit promotes evolution of hippocampal-cortical ensembles during memory consolidation

Hannah Twarkowski et al.
eLife | February 22, 2022
Memories encoded in the dentate gyrus (DG) ‒ CA3 circuit of the hippocampus are routed from CA1 to anterior cingulate cortex (ACC) for consolidation. Although CA1 parvalbumin inhibitory neurons (PV INs) orchestrate...

Bias-free estimation of information content in temporally sparse neuronal activity

Liron Sheintuch et al.
PLOS Computational Biology | February 11, 2022
Applying information theoretic measures to neuronal activity data enables the quantification of neuronal encoding quality. However, when the sample size is limited, a naïve estimation of the information content...

Hippocampal-amygdala memory circuits govern experience-dependent observational fear

Joseph I. Terranova et al.
Neuron | February 8, 2022
The empathic ability to vicariously experience the other’s fearful situation, a process called observational fear (OF), is critical to survive in nature and function in society. OF can be facilitated by both prior...

Stepwise synaptic plasticity events drive the early phase of memory consolidation

Akihiro Goto et al.
Science | November 11, 2021
Memories are initially encoded in the hippocampus but subsequently consolidated to the cortex. Although synaptic plasticity is key to these processes, its precise spatiotemporal profile remains poorly understood. Using...

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Publication Category: Hippocampus