Hippocampus Archives - Page 2 of 6

Control of contextual memory through interneuronal a5-GABAA receptors

Mengwen Zhu et al.
PNAS Nexus | April 11, 2023
γ-Aminobutyric acid type A receptors that incorporate α5 subunits (α5-GABAARs) are highly enriched in the hippocampus and are strongly implicated in control of learning and memory. Receptors located on pyramidal...

Septotemporal variations in hippocampal value and outcome processing

Miru Yun et al.
Cell Reports | February 9, 2023
A large body of evidence indicates functional variations along the hippocampal longitudinal axis. To investigate whether and how value and outcome processing vary between the dorsal (DH) and the ventral hippocampus...

Persistent representation of the environment in the hippocampus

Kyogo S. Kobayashi et al.
Cell Reports | January 11, 2023
In the hippocampus, environmental changes elicit rearrangement of active neuronal ensembles or remapping of place cells. However, it remains elusive how the brain ensures a consistent representation of a certain...

Disruption of hippocampal neuronal circuit function depends upon behavioral state in the APP/PS1 mouse model of Alzheimer’s disease

Heng Zhou et al.
Scientific Reports | December 6, 2022
The Alzheimer’s disease-associated peptide amyloid-beta (Aβ) has been associated with neuronal hyperactivity under anesthesia, but clinical trials of anticonvulsants or neural system suppressors have, so far,...

Hippocampal representations of foraging trajectories depend upon spatial context

Wan-Chen Jiang et al.
Nature Neuroscience | November 28, 2022
Animals learn trajectories to rewards in both spatial, navigational contexts and relational, non-navigational contexts. Synchronous reactivation of hippocampal activity is thought to be critical for recall and...

Forebrain Glucocorticoid Receptor Overexpression Alters Behavioral Encoding of Hippocampal CA1 Pyramidal Cells In Mice

Swapnil Gavade et al.
eNeuro | November 23, 2022
Glucocorticoid signaling influences hippocampal-dependent behavior and vulnerability to stress-related neuropsychiatric disorders. In mice, lifelong overexpression of glucocorticoid receptor (GR) in forebrain excitatory...

Exercise increases information content and affects long-term stability of hippocampal place codes

Yoav Rechavi et al.
Cell Reports | November 22, 2022
Physical exercise is known to augment brain functioning, improving memory and cognition. However, while some of the physiological effects of physical activity on the brain are known, little is known about its effects on...

Dose-dependent suppression of hippocampal contextual memory formation, place cells, and spatial engrams by the NMDAR antagonist (R)-CPP

Mengwen Zhu et al.
Neuropharmacology | August 14, 2022
We recently reported that the competitive NMDAR antagonist (R,S)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) does not suppress NMDAR-mediated field EPSPs (fEPSPNMDA) or long-term potentiation (LTP) in...

Multiple types of navigational information are independently encoded in the population activities of the dentate gyrus neurons

Tomoyuki Murano et al.
PNAS | August 5, 2022
The dentate gyrus (DG) plays critical roles in cognitive functions, such as learning, memory, and spatial coding, and its dysfunction is implicated in various neuropsychiatric disorders. However, it remains largely...

Noise correlations in neural ensemble activity limit the accuracy of hippocampal spatial representations

Omer Hazon et al.
Nature Communications | July 25, 2022
Neurons in the CA1 area of the mouse hippocampus encode the position of the animal in an environment. However, given the variability in individual neurons responses, the accuracy of this code is still poorly understood....

A weakened recurrent circuit in the hippocampus of Rett syndrome mice disrupts long-term memory representations

Lingjie He et al.
Neuron | May 18, 2022
Successful recall of a contextual memory requires reactivating ensembles of hippocampal cells that were allocated during memory formation. Altering the ratio of excitation-to-inhibition (E/I) during memory retrieval can...

Top-down control of hippocampal signal-to-noise by prefrontal long-range inhibition

Ruchi Malik et al.
Cell | April 28, 2022
Prefrontal cortex (PFC) is postulated to exert “top-down control” on information processing throughout the brain to promote specific behaviors. However, pathways mediating top-down control remain poorly understood....

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Publication Category: Hippocampus