Hippocampus Archives - Page 5 of 6

The Same Hippocampal CA1 Population Simultaneously Codes Temporal Information over Multiple Timescales

William Mau et al.
Current Biology | April 26, 2018
It has long been hypothesized that a primary function of the hippocampus is to discover and exploit temporal relationships between events. Previously, it has been reported that sequences of “time cells” in the...

Genetically encoded calcium indicator with NTnC-like design and enhanced fluorescence contrast and kinetics

D. A. Doronin et al.
BMC Biotechnology | February 13, 2018
We demonstrate that expanding the family of NTnC-like calcium indicators is a promising strategy for the development of the next generation of GECIs with smaller molecule size and lower Ca2+ ions buffering capacity as...

Anxiety Cells in a Hippocampal-Hypothalamic Circuit

Jessica C. Jimenez et al.
Neuron | January 31, 2018
The hippocampus is traditionally thought to transmit contextual information to limbic structures where it acquires valence. Using freely moving calcium imaging and optogenetics, we show that while the dorsal CA1...

Locus coeruleus input to hippocampal CA3 drives single-trial learning of a novel context

Akiko Wagatsuma et al.
PNAS | December 26, 2017
The memory for a new episode is formed immediately upon experience and can last up to a lifetime. It has been shown that the hippocampal network plays a fundamental role in the rapid acquisition of a memory of a...

Tracking the Same Neurons across Multiple Days in Ca2+ Imaging Data

Liron Sheintuch et al.
Cell Reports | November 24, 2017
Ca2+ imaging techniques permit time-lapse recordings of neuronal activity from large populations over weeks. However, without identifying the same neurons across imaging sessions (cell registration), longitudinal...

Distinct Neural Circuits for the Formation and Retrieval of Episodic Memories

Dheeraj S. Roy et al.
Cell | August 17, 2017
The formation and retrieval of a memory is thought to be accomplished by activation and reactivation, respectively, of the memory-holding cells (engram cells) by a common set of neural circuits, but this hypothesis has...

Dorsal-CA1 hippocampal neuronal ensembles encode nicotine-reward contextual associations

Li Xia et al.
Cell Reports | June 6, 2017
Natural and drug rewards increase the motivational valence of stimuli in the environment that, through Pavlovian learning mechanisms, become conditioned stimuli that directly motivate behavior in the absence of the...

Active dentate granule cells encode experience to promote the addition of adult-born hippocampal neurons

Gregory W. Kirschen et al.
The Journal of Neuroscience | April 3, 2017
The continuous addition of new dentate granule cells, exquisitely regulated by brain activity, renders the hippocampus plastic. However, how neural circuits encode experiences to impact the addition of adult-born...

Distinct hippocampal pathways mediate dissociable roles of context in memory retrieval

Chun Xu et al.
Cell | October 20, 2016
Memories about sensory experiences are tightly linked to the context in which they were formed. Memory contextualization is fundamental for the selection of appropriate behavioral reactions needed for survival, yet the...

Ventral CA1 neurons store social memory

Teruhiro Okuyama et al.
Science | September 30, 2016
The medial temporal lobe, including the hippocampus, has been implicated in social memory. However, it remains unknown which parts of these brain regions and their circuits hold social memory. Here, we show that ventral...

Direct imaging of hippocampal epileptiform calcium motifs following kainic acid administration in freely behaving mice

Tamara K. Berdyyeva et al.
Frontiers in Neuroscience | February 29, 2016
Prolonged exposure to abnormally high calcium concentrations is thought to be a core mechanism underlying hippocampal damage in epileptic patients; however, no prior study has characterized calcium activity during...

Hippocampal ensemble dynamics timestamp events in long-term memory

Alon Rubin et al.
eLife | December 18, 2015
The capacity to remember temporal relationships between different events is essential to episodic memory, but little is currently known about its underlying mechanisms. We performed time-lapse imaging of thousands of...

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Publication Category: Hippocampus